因應近代生物學之快速發展以及當代社會的需求，現行的國、高中生物課程網要中明訂 要納入生物科技相關之知識，以及學習科學與技術探究方法，以培養學生探索科學的興趣。 本文擬發展一個結合現代生物科技及科學家進行研究實例的探索課程，完成「小腦萎縮症疾 病模式研究」的教學棋組。内容在介紹基因轉殖技術於小腦萎縮症之醫療研究，同時訓練學生以邏輯思考解決研究問題。該模組經在中學講授後，欲達到課程的探索目標，施教高二學 生優於高一學生；施教於國中生，只能達到課程有限的探索目標，不過卻能達到極高的情意 目標。建議使用本棋組教學時應妥善設計情境問題；學生於小組討論與發言時，教師應適時 及適情境的引導，可使有意義的討論延伸更廣，以達成探索教學的目標。

In regarding to the rapid development of modern biology and demands of contemporary society, current biology curricular outlines of high school are needed to be including the biotechnology-related knowledge and learning methods of scientific and technical inquiry to enrich the students’ exploring scientific interests. This study developed an inquiry teaching module which combined the modem biological technology and exploration of scientists' case study. The established teaching module，the model study of spinocerebellar ataxia, contents to introduce gene transferred cell model and mouse model study of spinocerebellar ataxia in the medical research, meanwhile training students to think logically to solve research problems. After the teaching module has been taught, the courses to achieve exploration objects are better to teach senior high school students than that of junior high school students. When teaching in junior high school students, there is only reached limited inquire objects, however can achieve very high affective object. It was recommended that teaching this module properly when designing questions, group discussions，and teacher s suitable guidance will make meaningflil discussion at extending more wide level.