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放射治療與腫瘤學

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篇名 研究overshoot effect對於執行強度調控放射治療之影響及劑量修正
卷期 20:2
並列篇名 STUDY FOR THE OVERSHOOT PHENOMENON AND IMPROVING DELIVERY IN STEP-AND-SHOOT IMRT
作者 王思文游浚彥周文采朱俊男賴姿云翁益強楊世能梁基安
頁次 135-143
關鍵字 分段式強度調控放射治療多擊效應劑量率Step-and-Shoot Intensity-Modulated Radiation TherapyOvershootDose RateTSCI
出刊日期 201306

中文摘要

目的:強度調控放射治療已成為許多類型的癌症的標準輻射治療技術,如前列腺癌,頭頸癌,但執行分段式強度調控放射治療(step-and-shoot intensity modulated radiation therapy, SIMRT)時,當使用高劑量率(high dose rate)或低區段劑量(low dose per segment)時,會有明顯劑量不準確的現象,此現象在第一個區段(segment),輻射劑量會過多,及最後一個區段(segment)的劑量過少,稱之為多擊效應(overshoot effect)與少擊效應(undershoot effect)。本研究的目的是測量多擊效應影響程度,並找出校正方法,改善其影響,使實際給於病人的劑量與治療計畫上的,兩者無差異。材料與方法:在這次的研究中主要分為兩大部分:第一為對於不同劑量率,由每分鐘 100 監測單位(monitor unit, MU)至每分鐘 600MU,並使用不同區段劑量(segment dose),由每個區段照射 1MU至每個區段照射 10MU,分別進行多擊(Overshoot effect)效應程度研究,第二以阻擋修正(Block Correct)、交錯修正(Interlace Correct)、索引修正(Index Correct)三種修正技術,分別運用不同劑量率和不同區段劑量來量測比較討論,進行多擊效應程度研究。結果:研究測量多擊效應現象,其隨劑量率越高越明顯而區段劑量越低越顯著,其中當量測區段劑量為1監測單位/ 區段(MU/Seg)且處於劑量率 600 監測單位/ 分鐘,其多擊現象高達 52.5%以上。而三種修正技術均可達成修正效果給於正確劑量分布。阻擋修正(Block Correct)、交錯修正(Interlace Correct)、索引修正(Index Correct)分別將區段劑量為 1 監測單位/ 區段且處於劑量率 600 監測單位/ 分鐘下的多擊效應現象降至 -1.3%、-6.6%、0.1%。結論:本研究的目的是找到良好的校正方法,可避免當使用小監測單位和高劑量率使用時,多擊效應造成的區段劑量誤差(segment dose error)。三種修正方法的測量結果皆顯示可以用來改善分段式強度調控放射治療劑量不準確。

英文摘要

Purpose : Intensity-modulated radiation therapy (IMRT) has become a standard radiation deliverytechnique for many types of cancers such as prostate, head and neck and breast. The dosage was notprecise in step-and-shoot IMRT, while the radiation delivered with higher dose rate or lower dose persegment. The phenomenon is overshoot effect. It causes the higher dose at the first segment and lowerdose at the last segment. The purposes are that exam the dosimetric accuracy with overshoot effect,and improve the accuracy with corrections.Materials and Methods : There are two parts in the study. The first part is to exam the overshoot withthe dose rates, from 100 MU/min to 600 MU/min, and segment dose, from 1 MU per segment (MU/seg) to 10 MU/seg. The second part is to correct and measure the overshoot effect with block correct,interlace correct and index correct.Result : The overshoot effect cause higher dose at the first segment and lower dose at the last segmentwith higher dose rate and lower dose per segment. While the dose per segment is 1 MU and the doserate is 600 MU/min, the dosimetric error is up to 52.5%. The three corrections improved dosimetricaccuracy with the overshoot effect. Block correct, interlace correct and index correct reduce the dosefrom 152.5% to 98.7%, 93.4% and 100.1%, repectively.Conclusion : Clinically, it is possible to reduce the overshoot effect with with lower dose per segmentand higher dose rate. The three corrections improve the dosimetric accuracy for overshoot effect.

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