篇名 | Prevalence of Atrial Fibrillation in Patients with Brugada Syndrome in Taiwan |
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卷期 | 29:4 |
作者 | Jyh-Ming Jimmy Juang 、 Ching-Yu Chen 、 Yen-Bin Liu 、 Lian-Yu Lin 、 Wen-Jone Chen 、 Ling-Ping Lai 、 Chia-Ti Tsai 、 Jiunn-Lee Lin |
頁次 | 311-316 |
關鍵字 | Atrial fibrillation 、 Brugada syndrome 、 Taiwan 、 MEDLINE 、 SCI 、 Scopus |
出刊日期 | 201307 |
Purpose: The aim of this study was to assess the prevalence of atrial fibrillation (AF) in patients with Brugada syndrome (BrS) and their clinical characteristics in Taiwan.
Methods: The patient group consisted of 47 symptomatic BrS patients consecutively enrolled from 2000 to 2010. The definition of BrS patients with AF was a BrS patient with at least one episode of AF in a 12-lead electrogram or 24-hour holter (permanent, persistent or paroxysmal) during follow-up, or before diagnosis of BrS.
Results: Six BrS patients were identified with AF, and all ofthem were male. Two experienced sudden cardiac death (SCD), 2 presented with seizure and 4 with syncope. The mean age at onset of BrS was 47 土 16 years, similar to those BrS patients without AF (45 土 14,p = 0.67). Compared to those BrS patients without AF, significantly higher percentages ofthe BrS patients with AF presented with seizure and documented ventriculartachyarrhythmia (p = 0.02 and 0.03, respectively). Five of them had spontaneous Brugada type I electrogram, similar to those BrS patients without AF (p = 0.9). The SCN5A mutation rate is similar between BrS patients with AF and those without AF (p = 0.69). The prevalence of AF in BrS patients in Taiwan was 12.7% (6/47, 95% confidence interval 0.06-0.19) which is not significantly lower than the 20% prevalence found in the Caucasian population (p = 0.16). Conclusions: BrS patients with AF had distinct clinical features from those patients without AF in Taiwan.