目的：評估一醫學中心人數眾多的原發乳癌病人，接受手術後放射線治療的臨床病理特徵與治療成果。
材料與方法：自西元 1988 年到 2009 年間，連續有 1623 位乳癌病人在我們醫院接受完整療程的術後放射治療，所有病人均接受乳房全切除術或乳房保留手術，本研究分析其臨床病理特徵並統計治療成果。我們使用 Kaplan-Meier 存活分析方法來估計各項存活率，包含了疾病局部控制率、無遠端轉移存活率、無疾病存活率以及整體存活率（OS），另外使用 Cox 比例風險模式來分析哪些臨床病理特徵，是影響疾病局部控制率的預後因子。
結果：這 1623 位病人的追蹤期間自 2.3 個月至 23.0 年不等，中位數為 6.1 年。其中 83 位病人（5.1%）有局部復發，發生在手術後 4.7 個月至 12.5 年不等（中位數 2.0 年）。所有病人五年的疾病局部控制率、無遠端轉移存活率、無疾病存活率以及整體存活率分別為 95.1%、83.5%、79.8%、85.4%。在多變數分析中，腫瘤較大者、有淋巴結轉移、HER2 陽性、或三陰腫瘤（ER 陰性、PR 陰性、HER2 陰性），是局部復發的重要預測因子（所有P值 < 0.05）。有 39 位一開始即被診斷為第四期的病人，在接受手術及術後放射治療後，其五年的疾病局部控制率為 89.9%。
結論：放射線治療是非常有效的乳癌局部疾病控制的治療方法，三陰及 HER2 陽性是局部復發的重要預後因子。對於一開始即有遠處轉移的乳癌病人，積極的局部治療可以提高疾病的局部控制率。

Purpose : To evaluate our relative large institutional experience of the clinical-pathologic features and outcomes of radiation therapy in patients with operable primary breast cancer.
Materials and Methods : We reviewed 1,623 consecutive patients with operablebreast cancers which received complete course of adjuvant radiation therapy at our institution between 1988 and 2009. All patients underwent either mastectomy or breast conserving surgery (BCS) as part of their treatment. Clinical-pathologic and outcome parameters were analyzed. Kaplan-Meier product limit method was used to estimate loco-regional recurrence-free survival (LRFS), metastasis-free survival (MFS), disease-free survival (DFS) and overall survival (OS). Cox proportional hazards
models were performed to assess the prognostic significance of these clinicalpathologic parameters on LRFS.
Results : The median follow-up was 6.1 years (range, 2.3 months–23.0years). Among these 1623 patients, a total of 83 (5.1%) patients developed loco-regional recurrences,which occurred at 4.7 months to 12.5 years (mean, 2.0 years) after surgery. The 5-year LRFS, MFS, DFS and OS were 95.1%, 83.5%, 79.8%, 85.4% respectively for the entire cohort. Multivariate analyses showed that patients with advanced T stage, nodes positive, HER2 positive or triple negative tumors (ie, ER negative, PR negative and HER2 negative) had poor prognosis on LRFS (all P < 0.05). For 39 patients with initial stage IV breast cancer and receiving post-operation adjuvant radiotherapy, the 5-year loco-regional control rate was 89.9%.
Conclusions : Our results are consistent with others that radiation therapy is a very effective adjuvant treatment on loco-regional control in breast cancer patients. Triplenegative and HER2-positive profiles are prognostic markers for loco-regional recurrence.Aggressive local therapy improves local control in metastatic breast cancer.