酪氨酸酶是黑色素生成中主要的催化酵素，有許多活性分子就是藉由抑制其活性而達到降低黑色素生成之目的。去氧化熊果素就是其中一個被發現比熊果素與對苯ニ酚更有效也更安全的酪氨酸酶抑制劑。但是去氧化熊果素非常的不穩定，在水溶液中會因熱而分解成對苯ニ酚。
因此本研究藉由兩個有潛カ的配方系統希望可以促進去氧化熊果素的熱穩定性，分別是以自組裝之凱索尼酸（羧曱基己醯基化幾丁聚醣）包覆載體以及全油配方。本研究結果顯示自組裝之凱索尼酸包覆載體可以有效地減低去氧化熊果素在水溶液中的分解。以油脂溶液為主之全油配方也能夠明顯地保護去氧化熊果素不受熱誘發而降解。此外全油配方中由去氧化熊果素所釋放的對苯ニ酚含量亦顯著地下降。因此我們的結果顯示此兩種有潛カ的配方系統可以成功地促進去氧化熊果素之熱穩定性。

Tyrosinase is a key enzyme that is mainly involved in the formation of melanin. Many compounds have established inhibitory effects on melanogenesis through inhibitory activity for tyrosinase. DeoxyArbutin (dA) reveals greater inhibition of tyrosinase activity and to be safer than arbutin and hydroquinone. However, deoxyArbutin was thermolabile in aqueous solutions and decomposes to hydroquinone. Therefore, to increase the stability of deoxyArbutin in formulations, we chose two systems, self-assembled Chitosonic® Acid (Carboxymethyl Caprooyl Chitosan) capsules and oil formulation, as the formulations for investigation. The self-assembled Chitosonic® Acid nanospheres can successfully decrease the decay of deoxyArbutin in aqueous solution. Besides, for oil formulation, whole oil solution can obviously protect deoxyArbutin from the heat stimulated decomposition in its environment and then reduce the level of released hydroquinone in deoxyArbutin containing formulation. Therefore, our results demonstrated that both two potential systems can improve the thermostability of deoxyArbutin.