對愛滋感染者而言，無論是處於病程的哪一個階段，都很有可能歷經某種程度的心理壓力，此時如果無法採用適當的因應型態來面對疾病相關壓力，往往會出現許多不適應性的情緒。學者認為當我們教導愛滋感染者適當的壓力因應策略時，也應幫助他們發展出更深層的靈性，來促進患者的生活品質[1,2]。本研究以壓力互動模式探討知覺壓力及因應型態間的關係，驗證靈性為知覺壓力與憂鬱傾向間的中介因子，並與其他因應型態做比較。收案期間共從醫院及社區獲得65 份有效問卷，研究結果指出：一、靈性因應可緩衝知覺壓力程度，減少憂鬱傾向，且與主動式因應有顯著正相關。二、知覺壓力高者傾向使用逃避式因應，反之則傾向發展出靈性因應。最後根據本研究的發現，提供助人工作者在臨床愛滋照護實務上的建議。

No matter at which stage of the course of HIV infected patient is, he/she will probably endure some degree of psychological pressure. Researchers suggest that the quality of life improvement for HIV-positive persons should not only incorporate coping skill training, but also help them develop deeper spirituality[1,2]. For this reason, the study examines the relationships between perceived pressure and coping styles on the basis of stress transactional model. Spirituality is measured by examining the effect of the mediator between perceived pressure and the tendency of depression, and also comparing the coping effect with other coping styles. A total of 65 participants completed the questionnaires from community and hospitals in this study. The result points out that spirituality could buffer perceived pressure, reduce the tendency of depression, and it significantly correlates with active, positive coping style. HIV/AIDS status with high degree of stress incline to use avoidance coping style, on the contrary, those with low degree of stress incline to develop spiritual coping style. Finally, the discussion considers implications for HIV/AIDS clinical practice.