C型肝炎病毒一般常見侵犯肝臟引起肝臟病變，進一步引起肝硬化甚至肝癌；文獻上記載感染C型肝炎病毒尚有一些肝外病徵表現(extrahepatic manifestations)，尤其在腎臟部分常為人們忽略。膜性增生腎絲球腎炎(membranoproliferative glomerulonephritis)是最常見由C型肝炎引起之腎病變，其他如膜性腎病變(membranous nephropathy)、局部性腎絲球硬化症(focal segmental glomerulosclerosis)等也都有人報導過；除症狀治療外，在確定這些腎病變是由C型肝炎病毒所引起時尚可以抗病毒藥物、免疫抑制劑(immunosuppressive therapy)及血漿置換術(plasma-exchange)等治療；以下本文逐一討論。

The hepatitis C virus general encroaches upon the liver and causing the liver pathological change. Liver cirrhosis and even hepatocelluar carcinoma can be seen in patient with HCV infection. Except of liver, HCV can involve other organ and causing many extrahepatic manifestations, nephropathy is one of the most important extrahepatic manifestations that maybe neglected. Most of the HCV-related nephropathy is membranoproliferative glomerulonephritis, and membranous nephropathy, focal segmental glomerulosclerosis are also reported previously. Except of symptoms control, anti-HCV therapy, immunosuppressive therapy and plasma-exchange can be used for treatment of HCV related nephropathy.