This study evaluated the effects of combining the hemostatic agent bismuth subgallate (BS) with calcium phosphate bone cement (CPC) in hard-tissue regeneration. BS was added at 5，10，and 15 wt.% in CPC with 1 M phosphate hardening solution. The radiopacity，physiochemistry，hemostasis，and cytocompatibility were characterized. The data were statistically analyzed using one-way analysis of variance followed by Tuckey’s post-hoc test. The radiopacity of BS/CPC increased linearly with increasing BS content. The crystallite morphologies and X-ray diffraction patterns indicated a retardation effect on the phase transformation in all BS/CPC groups in vitro， resulting in a significant reduction in strength and prolonged setting time，but no significant changes in the relative working time，when compared with those of pure CPC. The analyses results show that 15 wt.% BS/CPC can shorten the blood clotting time by more than 50%. Moreover， the cell viability (as evaluated by the MTT assay) significantly increased after the addition of BS to a human osteosarcoma cell line (MG63) cultured for 1 and 24 h when compared with that obtained with pure CPC. The BS/CPC samples were highly radiopaque and are potential therapeutic candidates for shorting blood clotting time and thereby for correcting hemostatic failure and reducing bleeding risk in hypertensive patients.