藉由代謝症候群的篩選及早期治療，可減少心血管疾病的發生。然而，在高尿酸血症 的個體中，不同程度的尿酸値是否會影響代謝症候群之盛行率，臺灣本土的資料很少見，且血清尿酸値在這方面的潛在可利用性也很少被研究。爲了了解尿酸値與代謝症候群盛行率的相關性，我們蒐集了自西元2004年一月至十二月間，3065位某醫學中心的員工體檢資料加以分析，年齡從18至81歲（635位男性，2430位女性）。研究顯示，代謝症候群的盛行率，隨尿酸値的增加而呈現顯著的增加，相對危險比値（Odds ratio )亦有相同的結果，而尿酸値大於或等於9 mg/dL這組其代謝症候群出現的相對危險比値，在男女生組別分別是尿酸値小於5 mg/dL組的5.64及7.62倍。尿酸植越高的，具有多個代謝症候群組成因子的百分比亦隨著增加。各組再依年齡四分位數分析，代謝症候群的盛行率隨年齡增加而增加。本研究給我們『愈高的尿酸値，代謝症候群的危險性或盛行率增加』之訊息，甚至尿酸値處於正常範園内而其年紀較大者，亦値得我們小心代謝症候群的存在。因爲高尿酸血症常常伴隨有較高的代謝症候群盛行率，臨床上，應視高尿酸血症爲心血管疾病的一個重要的潜在標誌。

The occurrence of cardiovascular disease can be reduced by the screening and early treatment of metabolic syndrome. However, little information existed about whether different graded levels of uric acid in individuals with hyperuricemia will affect the prevalence of metabolic syndrome in Taiwan. The potential application of hyperuricemia was also studied little. To investigate the association between different uric acid levels and prevalence of metabolic syndrome, a total of 3065 subjects of all hospital staff, aged 18 to 81 years (635 males, 2430 females), who received health examination from Jan. 2004 to Dec. 2004 were enrolled in our study. The study showed that the prevalence of metabolic syndrome increased significantly across successive grade of serum uric acid concentrations, also the odds ratio (ORs) for the association between increasing levels of serum uric acid and the metabolic syndrome. Those who had serum uric acid concentrations 兰 9 mg/dL had a 5.18-fold increased in risk of metabolic syndrome, as compaired with those with concentrations < 5 mg/dL. Percentage of the more metabolic syndrome components increased as the serum uric acid concentrations increased. The prevalence of metabolic syndrome in each subgroup of the same uric acid level persisted in increasing across successive quar-tiles of age. This study indicate that high serum uric acid confers increased risk or prevalence of metabolic syndrome even for those whose uric acid levels are in the normal range but with higher age. In clinical practice, since high serum uric acid is associated with higher prevalence of metabolic syndrome, we must think hyperuricemia as an important potential marker for cardiovascular disease.