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內科學誌 Scopus

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篇名 Q熱--臺灣值得重視的新興感染症
卷期 19:1
並列篇名 Q Fever--An Emerging Infectious Disease in Taiwan
作者 陳柏齡李南瑤柯文謙
頁次 44-49
關鍵字 Q熱貝氏考克斯菌Q feverCoxiella burnetiiScopusTSCI
出刊日期 200802

中文摘要

Q热是由Cc»a_e//aZ)Mr«eft7(貝氏考克斯菌)所弓1起的人畜共通傳染病,急性表現以發燒、 肺炎、和肝炎爲主,慢性Q熱通常以感染性心内膜炎表現,而且發生於免疫機能缺陷的病 人。台灣報告的案例常合併急性肝炎或肝功能異常 < 需與本土常見的感染症 < 如恙蟲病 (scrub typhus)和斑療傷寒(murine typhus )作鑑別診斷。血清學檢查是重要的實驗室診斷工 具。臨床有效藥物包括四環徽素(tetracyclines)、氟化金林颜1類抗生素(fluoroquinolones)、石黄 胺類藥物(co-trimoxazole)和巨環徽素(macrolides)。孕婦和兒重的治療必須考慮藥物的致崎 胎性,磺胺類藥物和巨環黴素是治療選擇。

英文摘要

Q fever is a zoonotic infection caused by i'Wmeii1. Major clinical manifestations of acute Q fever include febrile illness, pneumonia, and hepatitis. Chronic Q fever usually manifests as infective endocarditis, and develops in immunocompromised hosts. In Taiwan, reported cases of Q fever usually present with acute hepatitis or abnormal liver functions, and physicians should make the differential diagnosis with endemic scrub typhus and murine typhus. Clinical diagnosis of Q fever relies on serological examinations. Effective antibiotics for Q fever include doxycycline, fluoroquinolones, co-trimoxazole and newermacrolides. Co-trimoxazole and macrolides are drugs of choice for pregnant women and children.

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