胃食道逆流疾病的流行，包括非糜爛性逆流疾病，正在幽門螺旋桿菌感染高盛行率的亞洲持續增加中。在關於非腐蝕性逆流疾病的大多數研究中並沒有提到幽門螺旋桿菌和pepsinogen (PG)，而且他們在胃食道逆流疾病中扮演的角色仍有爭論。這項研究是希望確定台灣華人非糜爛性逆流疾病病患的人口統計和血清學的特性。我們將連續六十九名到門診就醫的非糜爛性逆流疾病病患，和六十九名於臺大醫院接受包含胃鏡的年度健康檢查的健康人做對照比較。吾人分別測量幽門螺旋桿菌IgG血清陽性率和血清胃蛋白原（PGⅠ和PGⅡ）與gastrin。統計分析方法為卡方檢定 (Chi-Square Tests) 及獨立樣本U檢定（Mann-Whitney U test）。在非糜爛性逆流疾病的那一組和封照組加以比較，對照有較高seropositive IgG pylori比率 (37.7% v.s 59.4%: P<0.05)。在非糜爛性逆流疾病的那一組則有較高的PGⅠ(144.7±10.7ng/ml v.s 75.4±6.4ng/m1:P<0.05)和PGⅠ/Ⅱ比率(14.4±l0.7 v.s 9.l±0.7: P<0.01)：雨組有相似PGⅡ(12.0±0.8ng/ml v.s 10.5±1.1ng/ml: P=0.466)和gastrin(69.1±7.1pg/ml v.s 81.8±9.6pg/ml: P=0.318)。有非糜爛性逆流疾病的臺灣華人病患與對照組比較，他們有比較高的第一型胃蛋白原和較低的幽門螺旋桿菌血清陽性率。這些結果表明酸過多在非糜爛性逆流疾病中扮演的關鍵性的角色和在胃食道逆流疾病中幽門螺旋桿菌可能扮演的保護角色。

The prevalence of gastroesophageal reflux disease (GERD), including nonerosive reflux disease (NERD), is increasing in Asia where H. pylori infection is highly endemic. The role of H. pylori and pepsinogen (PG) has not been evaluated in most studies of NERD, and whether they play a role in GERD remains controversial. This study aimed to determine the demographic and serologic characteristics of Chinese patients with NERD. We prospectively enrolled 69 consecutive NERD patients, and as controls, 69 age- and gendermatched subjects who received endoscopy as a part of their annual health check-up. Rate of H. pylori IgG seropositivity, and serum levels of pepsin precursors (PGⅠ and PGⅡ) and gastrin were measured for each subject. Differences were analyzed using the Chi-square and Mann-Whitney U-test. The H. pylori IgG seropositive rate was lower in NERD patients than in controls (26/69, 37.7% vs. 41/69, 59.4%; p＜0.05). PGⅠ level was higher (144.7±10.7ng/ml vs. 75.4±6.4ng/ml; p＜0.001) and PGⅠ/Ⅱ ratio (14.4±10.7 vs. 9.1±0.7; p＜0.001) was higher in NERD patients than in controls, but both groups had similar PGⅡ (12.0±0.8ng/ml vs. 10.5±1.1ng/ml, p=0.466) and gastrin levels (69.1±7.1pg/ml vs. 81.8±9.6pg/ml, p=0.3l8). Chinese patients with NERD exhibit hyperpepsinogenemia I and a lower seropositive rate of H. pylori than age-matched controls. These results indicate a pivotal role of hyperacidity and possible protective role of H. pylori in this subset of GERD patients.