磷酸鈣塗層應用於增加醫療器械和生物傳感器與生物組織的相容性。相比傳統的熱噴塗，仿生塗層技術具有溫度低和無視線效應等優點。目前的仿生塗層制備方法僅適用於表面具有負電荷的基體，效率較低，並且需要強腐蝕性處理。本硏究報導一種廣泛適用於各種基體的仿生塗層制備方法。將基體進行親水性處理後，反覆浸入過飽和磷酸鈣溶液後於空氣中揮乾。此處理驅使磷酸鈣晶核在基體表面形成。將晶核覆蓋的基體再次浸入飽和溶液中，晶核迅速生長成均勻的磷酸鈣塗層。該方法已成功應用於鈦合金，聚乙烯，氧化鋁，乳酸-乙醇酸聚合物，以及石英等基體。

Calcium phosphate coatings can improve the biocompatibility of biomedical implants and biosensors. Compared with the currently standard thermal spraying, biomimetic calcium phosphate coating techniques have the advantage of lower processing temperature and non-line-of-sight effect. Current biomimetic coating methods, however, are slow, limited to substrates with negative surface charges and require highly corrosive treatments. We present here a new biomimetic coating method applicable for a wide variety of substrates. Substrates were treated to achieve a surface hydrophilicity, and then repeatedly dipped in a supersaturated calcium phosphate solution and dried in air. This repeated dip-and-dry treatment drove calcium phosphate crystallites to form on the surfaces of the substrates. The crystallite-covered surfaces were immersed in the supersaturated solution again, and these crystallites rapidly grew into uniform coatings. This method has been applied successfully on titanium alloys,polyethylene, alumin a, poly-lactide-co-glycolide and quartz.