雙酚A(Bisphenal A，BPA)會影響人類的內分泌系統，並可能會導致心血管疾病、致癌風險與糖尿病的罹患率增加。即使暴露劑量遠低於美國環保署認定的安全劑量50 μg/kg body weight/day，此物質對於動物和人體仍有不良的健康影響。全球目前BPA的需求量每年高達400萬噸以上，而台灣的製造與使用量皆為全世界第三高。本研究旨在瞭解國內BPA相關作業場所勞工的暴露現況與健康風險，並作為危害控制之參考。本研究選取4家作業工廠進行現場環境採樣與問卷收集，包括BPA作業、PVC保鮮膜與收縮膜工廠，共收集120組樣本，其中對照組為17人，暴露組為103人。以三層濾紙採樣器置於作業區域進行採樣，並利用HPLC/fluorescence detector進行分析。結果指出，4家工廠僅A廠空氣中量測到高濃度的BPA，其餘3廠之濃度則均為N.D.。顯示作業工廠中只有A廠勞工為BPA的職業暴露族群，平均濃度為33.32±112.08 μg/m3，範圍介於0.01-652.02 μg/m3，至於其他三廠之勞工則應可排除職業暴露風險。此外，若單就A廠勞工的工作類別來看，儘管BPA暴露的非致癌健康風險危害指標小於1，但研究仍發現其現場作業區域環境空氣中的BPA濃度(平均濃度為52.81±138.80 μg/m3)顯著高於其他區域(濃度範圍介於N.D.- 1.78 μg/m3)。同時本研究也發現，A廠空氣中BPA濃度顯著高於過去其他研究結果。儘管目前我國並未訂定BPA作業環境容許濃度標準，但有鑑於BPA對人體的健康危害顯著，建議有關單位應盡速建立適當的容許濃度標準，以降低作業勞工的暴露危害與健康風險。

Bisphenal A (BPA) has been demonstrated to be both estrogenic and anti-androgenic, leading to a decrease in sperm production in humans and abnormal development of puberty in experimental animals. It may also increase carcinogenic risk, prevalence of cardiovascular diseases and diabetes in humans. As the production and consumption of BPA is growing dramatically around the world, more and more workers expose to BPA in workplace. Given the potential adverse effects of BPA on human health, it is necessary to assess the occupational exposure levels of workers and establish exposure limits to protect them. The purposes of this study are to determine the ambient BPA levels for workers in PVC film manufacturing industry and to evaluate the workers’ health risk. Four plants were chosen as sampling sites, and 120 workers were invited to participate in the study. A structured questionnaire was distributed to collect demographic and exposure data. All workers were divided into BPA-exposure group and control group, containing 103 and 17 workers respectively. Air samples were collected by using 3-piece filter cassettes, which loaded glass-fiber fibers. BPA were measured by means of HPLC with fluorescence detector. The results showed that the possibility of exposing BPA occupationally could be excluded in PVC film plants (B, C, and D) in this study. Nevertheless, we also found that the workers in plant A exposed high level of BPA. The mean concentration in operation area was 52.81±138.80 μg/m3, with concentrations ranging from0.01 to 652.02 μg/m3, while the levels of other areas were N.D.-1.78 μg/m3. Furthermore, the BPA concentrations in plant A were also much higher than those in previous studies. We recommend that occupational permissible exposure limit and effective prevention measures should be established to protect the health of workers.