多囊性卵巢疾病主要病因病機，為先天稟賦腎陽不足，造成後天體質脾陽亦不足，進而形成脾陰虛肝旺，反過來更加耗損卵巢真陰，致陰虛陽亢，癸水中雌激素分泌減少，而雄激素分泌增加，其結果雄激素抑制卵泡發育而形成多囊卵巢。雌激素作用於下視丘及腦下垂體回饋調節失常而導致月經失調、稀發月經，甚則經閉。素體脾陽不足，若加上過食生冷、肥甘厚味，內傷脾胃，將使血中痰濁脂膏及甘味過盛，而導致肥胖經閉、不孕，嚴重者引起糖尿病、脂肪代謝異常及高血壓。多囊性卵巢疾病為本虛標實之證，以脾腎虛為本，痰濕、血熱為標。痰濕多以經閉肥胖為主要臨床表現；血熱則多以多毛症、青春痘表現。其治療原則，必須掌握病機而加以辨證施治。

The cause and pathological mechanism of polycystic ovary disease was congenitalkidney yang insufficiency which influenced acquired spleen yang insufficiency,and performed spleen yin vacuity and effulgent liver pattern. The results consumedand damaged ovary true yin that induced yin vacuity and hyperactive yang whichcausing estrogen secretion decreased and androgen secretion increased. Androgeninhibited oocytes development and performed a polycystic ovary. The feedbackregulation imbalance of estrogen acting to hypothalamus-pituitary gland that irregularmenstruation, or oligomenorrhea, even amenorrhea should be happen. The constitutionof body was spleen yang insufficiency pattern, if adding excessive consumptionof raw and cold foods as well as fatty and sweet foods that caused the spleen andstomach internally damaged which will be produced phlegm turbidity of lard andsweet excessive in the blood that may cause obesity, amenorrhea and infertility, evendeveloped diabetes, lipid metabolism abnormality and hypertension. Polycystic ovarydisease was a disease pattern of root vacuity and tip repletion. The root vacuity was thekidney and spleen insufficiency. The tip repletion was phlegm-damp and blood heat.The main manifestation of phlegm-damp pattern in clinic was obesity and amenorrhea.The blood heat pattern was most shown hirsutism and acne. The treatment principles ofpolycystic ovary disease must hold pathological mechanism as well as identify patternsand administer treatment.