唐氏症者的平均餘命增加，可能因為提早老化而導致先天疾病惡化或罹患嚴重的慢性疾病，如何維持並提升唐氏症者的健康品質是重要的課題；唐氏症者若能夠擁有良好的日常生活功能，則可以獨自完成常見的生活事務，減少照顧者的負擔。本研究使用PubMed、Medline、Google Scholar及華藝線上圖書館等資料庫，搜尋關鍵字中文包含「唐氏症(down syndrome)」、「日常生活功能(activities of daily living)」及「生活品質(quality of life)」等文獻，探討影響唐氏症者日常生活功能的影響因素。結果發現，比較唐氏症者與一般智能障礙者的日常生活功能，在兒童、壯年或老年時期唐氏症者的日常生活功能都有相對較差的情形，而導致唐氏症者日常生活功能下降的因素為老化，可能肇因於老化併發的相關疾病、身體活動能力下降、以及失智症的發生，但唐氏症者若能正常投入職場工作，則其日常生活功能則可能維持較好的狀態。本研究建議相關單位重視唐氏症者老化問題，並幫助他們增強社會參與能力與機會，以維持獨立的日常生活功能。

The life expectancy of Down syndrome is increasing, but the consequence of aging - chronic disease and Alzheimer's disease could cause a poor health quality of this population. Therefore, how to maintain and improve better activities of daily living (ADL) in people with Down syndrome will be an important issue in health policy. Good ADL function of people with Down syndrome means independence in daily living, and those people could reduce the burden of caregivers, and to improve their quality of life. The present paper aims to understand relation of ADL and quality of life in people with Down syndrome based on recent article reviews by searching at database of PubMed, Medline, Google Scholar and CEPS, and related reports for the keyword of Down syndrome, activities of daily living, and quality of life. The review found that those people with Down's syndrome compare their ADL to individuals with intellectual disabilities have a relatively poor ADL, and aging factor led to decreased ADL condition and decreased physical activity and increase the incidence of dementia of persons with Down's syndrome. Those people with Down's syndrome involve into the paid workplace, it is possible to improve their quality of life. This study highlights that we should pay much attention to aging problems of people with Down's syndrome, to strengthen their ability to participate activities in society to maintain their physical functioning.