目的：肝硬化患者常有肝性腦病變，此影響其認知能力，近似於失智。本研究欲檢驗用於快速篩檢失智症的神經心理測驗是否適用於輕微型肝性腦病變患者（未達臨床標準）。受檢驗的神經心理測驗為：認知能力篩檢測驗（Cognitive Ability Screening Instrument; CASI）與簡式智能測驗（Ｍini-Mental State Examination; MMSE）。
方法：肝硬化患者來源為高雄長庚醫院門診醫師轉介。排除已符合肝性腦病變之患者，共計收納27位肝硬化患者，並依照其神經心理測驗之結果分成兩組：輕微型肝性腦病變組（計14位）與無肝性腦病變組（計13位）。由其他正在進行的腦功能研究招募健康受試者共24名。本研究統計分析採用單因子變異數分析（ANOVA）。
結果：輕微型肝性腦病變者與健康參與者在認知能力篩檢測驗的總分有顯著差異；簡式智能評估表則無。使用認知能力篩檢測驗偵測輕微型肝性腦病變的切截總分為95.25；抽象概念分測驗切截分數為9.5。
結論：認知能力篩檢測驗對偵側輕微型肝性腦變者有其敏感度，但簡式智能評估表則不建議用於臨床評估肝性腦變。

Objective: Patients with severe cirrhosis often have minimal or overt hepatic encephalopathy (HE), which show cognitive disturbances. This study aimed to explore the ability of Cognitive Ability Screening Instrument (CASI) and Mini-Mental State Examination (MMSE) to detect the cognitive impairment in cirrhotic patients with HE.
Methods: Twenty-seven cirrhotic patients were studied: 14 cirrhosis with minimal HE and 13 cirrhosis without minimal HE. Twenty-four healthy volunteers were recruited as a control group. The Chinese version of CASI (CASI C-2.0) and MMSE were applied. Analysis of variance was used.
Results: The abstraction subset and total score of CASI C-2.0 were found a statistically significant difference between cirrhotic patients with the minimal HE and the control group. The cutoff values of the abstraction subset and total score of CASI C-2.0 for detecting the cirrhotic patients with minimal HE were 9.5 and 95.25.
Conclusion: This study suggests that the abstraction subset and total score of CASI C-2.0 can be the indexes to detect the minimal HE at clinics.