目的：探討咖啡因對中高強度間歇運動後超額攝氧量 (excess post exercise oxygen consumption, EPOC) 的影響。方法：8 位健康男性受試者 (年齡：24.4 ± 0.3 歲、身高： 174.7 ± 2.4 公分；體重：70.8 ± 2.8 公斤；V ‧ O2peak：38.6 ± 1.7 mg/kg/min) 參與兩次平衡 交叉，雙盲且間隔至少一週的實驗處理，一次攝取250 毫克的咖啡因膠囊，一次則為 安慰劑，兩次增補後統一安靜休息90 分鐘，隨即進行中高強度運動，運動方式為先以60% V ‧ O2peak 的強度進行腳踏車運動20 分鐘後，再進行3 組80% V‧O2peak 運動 1 分鐘，休 息1 分鐘的間歇性腳踏車運動。採集受試者攝取咖啡因或安慰劑後第0、25、55、85 分 鐘之安靜心跳率 (heart rate, HR)、呼吸交換率 (respiratory exchange ratio, RER) 及攝氧量 (oxygen uptake, V ‧ O2)。實驗過程中也採集受試者增補前 (pre-90)、運動前立即 (pre-exe)、 運動後恢復期的第4 分鐘、240 分鐘及480 分鐘 (post-4、post-240、post-480) 之前臂靜 脈血液，以及運動後60 分鐘之攝氧量。統計方法以相依樣本t 考驗檢定總EPOC、快速 期EPOC 及慢速期EPOC；以重複量數雙因子 (treatment × time) 變異數分析考驗HR、 RER、V ‧ O2 及血乳酸濃度之交互作用及差異顯著情形。結果：安靜攝氧量部分，時間與 組別交互作用達顯著 (F = 7.68, p = .028)，咖啡因處理在第25 分鐘 (5.50 ± 0.36 ml/kg/min, p = .004)、第55 分鐘 (5.17 ± 0.21 ml/kg/min, p = .032) 及第85 分鐘 (5.36 ± 0.23 ml/kg/min, p = .010) 之攝氧量，皆顯著高於第0 分鐘 (4.35 ± 0.19 ml/kg/min)。EPOC 部分，僅咖啡 因處理 (750.86 ± 91.39 ml) 之EPOC 快速期顯著高於安慰劑處理 (600.27 ± 72.19 ml) (p = .043)。結論：攝取250 mg 咖啡因可顯著增加安靜時代謝速率，及中高強度間歇運動後 之能量消耗，若日後欲進行中高強度間歇運動，且欲增加能量消耗時，建議可於運動前 搭配攝取咖啡因。

Purpose: To investigate the effect of caffeine on excess post exercise oxygen consumption (EPOC) after moderate-high intensity exercise. Method: Eight healthy males (age: 24.4 ± 0.3 yr, height: 174.8 ± 2.4 cm, weight: 70.8 ± 2.8, V ‧O2peak: 38.6 ± 1.7 ml/kg/min) attended two randomized, cross-over, double-blind trials at least one week apart, one with 250 mg caffeine (Caf) and one with placebo (0 mg caffeine; Pla), and after 90 min rest then completed each exercise session (ES) on cycle ergometer. ES consisting of 20 min of cycling at 60% V ‧O2peak follow by 3 sets of 1-min cycling at 80% V ‧O2peak with a 1-min rest between sets. During each ES, resting V ‧O2 and 60-min post-exercise V ‧O2 were measured. Blood sample were drawn at 90 min before exercise, pre - exercise, and 30 min, 240 min, 480 min after exercise. Plasma was analyzed for lactate. V ‧O2 was measured for the 60 min after the exercise. Data from total EPOC, fast phase EPOC, and slow phase EPOC were analyzed by paired t-tests and p < .05 was considered statistically significant. HR, RER, V ‧ O2 and lactate were compared initially through two-way (treatment × time) ANOVA with repeated measures. Result: No significant difference in HR and RER. However, the interaction effect of treatment and time on V ‧O2 was statistically significant (F = 7.68, p = .028). V ‧O2 was significantly increased at 25 (5.50 ± 0.36 ml/kg/min), 55 (5.17 ± 0.21 ml/kg/min) and 85 min (5.36 ± 0.23 ml/kg/min) than before (4.35 ± 0.19 ml/kg/min) (p = .004, p = .032, p = .010) supplementation in caffeine trail. Fast phase of EPOC in caffeine trail was significantly higher than placebo (750.86 ± 91.39 ml vs. 600.27 ± 72.19 ml, p = .043). Conclusion: Ingestion of caffeine 250 mg could increase the ratio of rest metabolism, as well as after middle- high intensity interval exercise.