目的：探討高地與平地之單次耐力運動，所造成氧化壓力之影響。方法：招募健康 研究對象18 位 (男性10 位及女性8 位，年齡：20.3 ± 0.4 歲、身高：165.9 ± 8.0 公分與 體重：59.5 ± 12.0 公斤)。藉由隨機交叉方式在高地與平地環境進行耐力運動時，分析其 安靜 (Pre)、運動後立即 (Post) 與運動後 (10 min、60 min、120 min 與240 min) 的血漿 生化指標。各項分析所得的數據均以平均數 ± 標準誤表示。以重複量數雙因子 (環境* 時間) 變異數分析考驗其差異程度，顯著性訂為p < .05。結果：血比容 (hematocrit, Hct)、 乳酸 (lactate)、尿酸 (uric acid) 與葡萄糖 (glucose) 濃度，環境主要效果達顯著差異；高地 顯著高於平地環境 (p < .05)。高地耐力運動後血漿總蛋白、羰基蛋白 (carbonyl proteins)、 硫代巴比妥酸反應物 (TBARS) 與氮氧化物 (NOx) 濃度；超氧離子歧化酶 (SOD)、麩胱 甘肽過氧化酶 (GPx) 與過氧化氫酶 (CAT) 活性，與平地從事耐力運動相比並無顯著的 差異 (p > .05)。結論：急性高地 (2,400 m) 耐力運動可能不會造成氧化壓力，但會增加 代謝壓力。

Purpose: To compare the effects of high-altitude and sea-level acute endurance exercises on oxidative stress. Methods: Eighteen healthy subjects (10 men and 8 women, age: 20.3 ± 0.4 yrs, height: 165.9 ± 8.0 cm, weight: 59.5 ± 12.0 kg) were recruited and randomly assigned to high-altitude or sea-level environment for acute endurance exercise. Blood samples were collected at resting (Pre), post-exercise (Post), post-exercise 10 min, post-exercise 60 min, post-exercise 120 min, and post-exercise 240 min for analyzing the plasma biochemical indicators. All data were denoted by the mean ± standard error. Repeated measures two-way (environment * time) analysis of variance was adopted to test the mean differences. The level of significance was set at p < .05. Results: Environmental effects on hematocrit (Hct), lactate, uric acid and glucose concentrations were significantly higher at high altitude than those at sea level (p < .05). After endurance exercise in high-altitude environment, total plasma proteins, carbonyl proteins, thiobarbituric acid reactive substance (TBARS), nitrogen oxides concentrations (NOx), superoxide dismutase activity (SOD), glutathione peroxidase activity (GPx) and catalase activity (CAT) were non-significantly different from those in sea-level environment (p >.05). Conclusion: Acute endurance exercise at high altitude (2,400 m) might not cause oxidative stress, but would increase metabolic stress.