Among the Studies of naturally occurring compounds of all kinds, flavonoids chemistry has emerged from the undirected search for new compounds and the establishment of their structures by conventional means and has been increasingly directed into areas of enquiry which biological consideration comes to play an increasingly important role. Medicinal plants constitute an effective source of traditional and modern medicines. The present research work deals with phytochemical and pharmacological studies of Leucas aspera. The fresh flowers of Leucas aspera have been found to contain Baicalein and Baicalin. The isolated compounds have been duly characterized by chromatographic and hydrolytic study as well as by UV spectral means. The membrane interaction of albino rat RBC with isolated Leucas aspera flavonoids by an in vitro method has been studied.