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中西整合醫學雜誌

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篇名 比較中醫期刊文獻與臺灣健保資料庫乳癌研究之用藥差異
卷期 17:3
並列篇名 Comparison of Chinese Medicine Used Patterns Among Breast Cancer by Literature Review and by Analysis of NHIRD in Taiwan During 1998-2008
作者 陳婉伶蔡嘉一黃怡嘉
頁次 017-024
關鍵字 乳癌中醫文獻回顧台灣全民健保資料庫Breast CancerChinese MedicineLiterature ReviewNHIRD
出刊日期 201509

中文摘要

惡性腫瘤為國人十大死因之首,乳癌更為102 年十大癌症死因第四名。據2013 年賴 榮年教授「臺灣乳癌婦女1998~2008 年間的中藥使用率及模式分析」的研究論述,台灣女 性新診斷乳癌後尋求中醫藥治療者佔八成以上,但其為台灣健保資料庫之統計結果,並無 中醫文獻之論述。故本研究藉由回顧與乳癌病因病機、證型、常用方劑與藥物相關之中醫 期刊文獻,歸納傳統醫學在面對乳癌之病機思路,並嘗試與賴教授研究中,台灣乳癌婦女 就診中醫最常使用的方劑和藥物結果比較,以供臨床治療參考。 本研究發現,傳統醫學常用之乳癌病因有情志內傷、先天不足等;經西醫治療前乳癌 患者常見證型為肝氣鬱滯、痰、瘀等,經西醫治療後常見證型轉為脾氣虛、瘀、血虛等; 常用之方劑前三名為逍遙散、六味地黃湯、桃紅四物湯;常用之藥物前五名為黃耆、茯苓、 白朮、黨參、半夏,其中於手術後常用藥有桑枝、薑黃等,化療後常用藥有女貞子、竹茹 等。此結果與賴教授之研究結果有很大的不同,可能是(1) 健保資料庫規模龐大和文獻規 模不同,導致統計上的差異;(2) 患者診斷雖為乳癌,但和就診實際問題有落差;(3) 乳癌 患者期別不同,也會影響治則和用藥。

英文摘要

Cancer is the leading cause of death in Taiwan, while breast cancer is the fourth leading cause of death for females in 2013. Based on professor Jung-Nien Lai’s research“Prevalence, Pattern, and Costs of Chinese Medicine Use among Breast Cancer Women in Taiwan during 1998-2008”, up to 80% of women with newly diagnosed breast cancer used TCM outpatient services. Above research were statistical results of NHIRD. No related literature review on the usage of Chinese Medicine among women with breast cancer has been reported. We analyzed causes, pathomechanism, pattern types, formulas and drugs of Chinese Medicine treatment among women with breast cancer by literature review, summarized thinking processes of pathomechanism, and compared these results with Professor Lai’s research. We hope that these results could provide a useful referrence of clinical practice. We found that the leading cause of breast cancer are internal injuries caused by seven emotions and insufficiency of innate endowment. For the patients with breast cancer, the common pattern types before Western medicine treatment are liver qi depression, phlegm and blood stasis , while the common pattern types after Western medicine treatment are spleen qi vacuity, blood stasis and blood vacuity. Xiao-yaosan, Lliu-wei-de-huang-tang and Tao-hong-si-wu-tang are the three most frequently prescribed formulas. Astragalus membranaceus, Atractylodes macrocephala, Poria cocos, Codonopsis pilosula and Pinellia ternate are the top five prescribed single herb. Among them, Morus alba and Curcuma longa are commonly used drugs after surgery, while Ligustrum lucidum and Bambusa tuldoides Munro are commonly used after chemotherapy. These findings are significantly different from the results of Professor Lai’s research. It may due to the statistical discrepancy caused by the sample size of literature review and NHIRD or difference between clinical diagnosis and actual health problems. Different needs of TCM treatment for the different stages of breast cancer may also influence the results.

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