溶液中的囊泡在與疏水固體界面相互作用過程中發生融化破裂並重排，這一 物理現象已經被作為生物膜模型以及生物物理和傳感器應用的一部分被廣泛研究。在本論文中，我們利用石英晶體微天平(Q-CMD)技術，在溫度為30°C時， 實時研究了以兩種不同比例構成的囊泡體系在十八烷基硫醇處理的疏水界面的融 化、破裂、重排的動力學特徵。研究中，我們觀察和比較了囊泡在疏水表面的不 同吸附動力學特徵，針對不同囊泡體系提出了可能的幾種吸附方式：(1)囊泡在 疏水表面形成單層膜，(2)囊泡完整的吸附在疏水表面，(3)囊泡在疏水界面形成 多層脂質膜。與此同時，我們研究了伴刀豆球蛋白(Con A)在脂質層的吸附，通 過Voigt數學模型估算了脂質層以及蛋白的厚度。研究表明脂質層和蛋白的吸附量 不僅與脂質層的密度有關，還與其空間位阻有密切聯繫，此結果與之前利用表面 等離子技術(SPR)研究分析的結論相一致。

The fusion of vesicles onto solid substrates from solution has been developed as an alternative as biomembrane models as well as part of biophysics and biosensor application by interaction of vesicles with the hydrophobic interface. In the present study, we investigate the vesicle adsorption kinetics of three systems on hydrophobic surfaces formed by alkanethiols self-assembling process via surface-induced destabilization and rupturing at 30°C in real time, using dissipative quartz crystal microbalance (QCM-D) technique. We observe differences in the thickness of lipid monolayer and likely three adsorption pathways have been identified depending on different systems: (1) monolayer formation on the hydrophobic surface, (2) intact vesicle adsorption, (3) multi-lipid layers formation. Followed protein adsorption onto the lipid monolayer with structural changes have also been investigated and we get information not only about the thickness of protein adsorption but also about its viscoelastic properties by using Voigt model. It is clear that the amount of specifically bound Con A is related not only to surface density of the ligands but also to steric crowding of the ligands.