研究顯示桑黃 (Phellinus linteus)具有保護肝臟、增強免疫力及抗氧化等生理作用，本研 究目地在探討桑黃對老化促進小鼠學習記憶能力之影響。實驗以六月齡SAMP8 (senescence-accelerated mouse prone-8；SAMP8) 小鼠為對象，分為四組，每組十隻，分成控 制組 (1.00ml double-distilled water) 和桑黃實驗組 (低劑量組200mg/kg BW/day、中劑量組 500mg/kg BW/day 和高劑量組1000mg/kg BW/day) ，每週紀錄體重變化、攝食量及飲水量。 管灌餵食8 週，於第8 週進行活動量試驗;第9 週進行學習記憶能力測試，犧牲後檢測血液生 化值。結果顯示，實驗組之攝食量、體重變化及活動量均無顯著差異。血液低密度脂蛋白、 總膽固醇及三酸甘油酯濃度顯著減少 (p <0.05) ，高密度脂蛋白部分實驗組別有增加趨勢； 丙胺酸轉胺酶部分實驗組較控制組有下降之現象；桑黃組之主動及單次被動迴避試驗亦有較 佳之學習記憶能力表現 (p<0.05) ，綜合上述，桑黃可能具有改善SAMP8 小鼠之學習記憶能力。

Research showed that Phellinus linte has protect the liver, immune-enhancing effects and anti-oxidation. The purpose of this study was to investigate the effects of Phellinus on learning and memory ability in senescence-accelerated mice (SAMP8) . 6-month-old SAMP8 male and female mice were used in this study. SAMP 8 mice were randomly divided into four groups, where each group contained 10 mice, including control group, into the control group (1.00ml double-distilled water) and Phellinus groups (low-dose group 200mg / kg BW/day, the middle dose group 500mg / kg BW/day and the high dose group 1000mg / kg BW/day) . The body weight, food intake and water consumption were measured every week. The 8th week, the open field activity test was recorded in evaluation for behavior. One week before scarification, the single-trail passive avoidance test and active shuttle avoidance test were performed. The biochemical parameters of serum were analyzed after the mice sacrificed. The results showed that there was no significant difference in the body weight, food intake, and locomotion among each group. Blood LDL, total cholesterol and triglyceride levels significantly decrease (p<0.05) , there is Part of the experimental group an increasing trend of high-density lipoprotein; Glutamic-Oxaloacetic Transaminase, Glutamic-Pyruvic Transaminase decreased compared with the control group. Results from single-trail passive avoidance test and active shuttle avoidance test showed that experimental groups had significantly better learning memory ability (p<0.05). In summary, Phellinus linte may be improve the learning memory ability in SAMP8 mice.