背景和目的：退化性膝關節炎合併糖尿病患者，需接受全膝關節置換術的人口隨年齡增長而逐漸 增加，新式微創全膝關節置換術相較傳統型全膝關節置換術增添許多優點，故於臨床使用上普遍 率提高。本篇研究目的為比較糖尿病患者與無糖尿病者接受微創全膝關節置換術後，其術後身體 功能恢復和生活品質狀況，並探討影響術後成效的影響因子。方法：徵召93名進行微創全膝關節 置換術患者，分為糖尿病組與非糖尿病組（糖尿病組46人，非糖尿病組47人）。分別在術前一日 和術後三個月進行測量評估，包含雙側膝關節屈曲活動度、雙側股四頭肌肌力、身體功能測試、 身體活動量，退化性關節炎指標和生活品質。結果：經身體質量指數調整後，兩組受試者術後三 個月非開刀側股四頭肌肌力（P=0.007 )、六分鐘行走測試(p=0.001)及36題簡短版生活品質量表的 身體角色（p=0.021)和一般健康（p=0.039)領域有顯著組間差異。術後六分鐘行走測試距離和術後 非開刀側膝關節屈曲活動度、股四頭肌肌力術、前六分鐘行走測試距離，以及是否罹患糖尿病有 顯著相關（調整後R2=72.6%，p<0.001)。經共變數調整後，顯示糖尿病並非主要影響術後身體功 能和生活品質的獨立因子。結論：糖尿病患者經微創全膝關節置換術後三個月有較差的身體功能 和生活品質。術後膝關節屈曲角度和股四頭肌肌力與術前身體功能是主要術後身體功能和生活品 質的主要預測因子。

Background and Purpose: The population coexisted with knee osteoarthiitis (OA) and diabetes mellitus (DM) requiring total knee arthroplasty (TKA) increases with aging. The new minimally invasive TKA (MIS-TKA) prevails due to its advantages. This study aimed to compare physical function recovery and quality of life (QOL) after MIS-TKA in patients with DM to those without, and to deteraiine the factors influencing the postoperative outcomes. Methods: Ninety-thiee patients underwent MIS-TKA were recruited and divided into diabetic group and non-diabetic group (46 in diabetic group and 47 in non-diabetic group). The measurements were assessed before sur-geiy and at 3-month follow-up, including range of motion (ROM) of knee flexion and quadriceps strength, physical function tests, physical activities, osteoarthritis index, and QOL. Results: There were significant between-group differences at preoperative and 3 months in quadriceps strength of non-operated side (p=0.007), 6-minute walk test distances (p=0.001), and role-physical (p=0.021) and general health domains (p二0.039) of QOL after adjustment for body mass index. The 3-month follow-up 6MWT distances were associated with preoperative 6MWT distances, postoperative knee flexion ROM and quadriceps strength of non-operated side, and the non-diabetic group (adjusted 7?2=72.6%,/?<0.001). However, diabetes was not a major independent factor associated with postoperative physical function and QOL while adjusting for covariates. Conclusion: Compared to patients without DM, patients with DM had worse physical function and QOL at 3-month follow-up. Postoperative knee flexion ROM, quadriceps strength, and preoperative physical function status were major predictors of postoperative physical function and QOL in patients receiving MIS-TKA.