篇名 | Predictive Value of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Patients with Coronary Slow Flow |
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卷期 | 32:3 |
作者 | Mustafa Çetin 、 Emrullah Kiziltunc 、 Özgül Uçar Elalm 、 Zehra Güven Çetin 、 Muhammed Bora Demirçelik 、 Hülya Çiçekçiolu 、 Alparslan Kurtul 、 Selçuk Özkan 、 Candan Mansurolu Avan 、 Ender Örnek 、 Feridun Vasfi Ulusoy |
頁次 | 307-312 |
關鍵字 | Coronary slow flow 、 Inflammation 、 Neutrophil lymphocyte ratio 、 Platelet lymphocyte ratio 、 MEDLINE 、 SCI 、 Scopus |
出刊日期 | 201605 |
DOI | 10.6515/ACS20150119I |
Background: Increased microvascular resistance due to chronic inflammation is assumed to be one of the mechanisms associated with coronary slow flow (CSF). Previous studies have shown that the platelet-to-lymphocyte ratio (PLR) and the neutrophil-lymphocyte ratio (NLR) are markers of inflammation for various diseases. In this study we aimed to evaluate the relationship between CSF and PLR-NLR. Methods: Seventy-eight patients with CSF and 50 patients with normal coronary flowwere enrolled into this study. The study subjects underwent medical examination and testing, after which their platelet-to-lymphocyte ratios and NLR values were calculated. An independent observer measured the coronary flow rate by Thrombolysis in Myocardial Infarction Frame Count (TFC)method. The platelet-to-lymphocyte ratio and NLR valueswere compared between the groups and correlation analysis was performed to explore the relationship between mean TFC with PLR and NLR. Results: Platelet-to-lymphocyte ratio and NLR values were significantly higher in patients with CSF (p < 0.001). There was a positive significant correlation between TFC with NLR and PLR (Spearman’s Rho: 0.59, p < 0.001 and Spearman’s Rho: 0.30, p = 0.001, respectively). Multivariate logistic regression analysis revealed that NLR is the one independent predictor for CSF. Conclusions: This study demonstrated an association between CSF and PLR-NLR. Although the exact mechanism could not be explained, our findings support the possible role of inflammation in CSF physiopathology.