猴頭菇可調節免疫力，對消化系統的癌變及潰瘍均有顯著療效。本研究之目的為評估猴頭菌液態發酵米 漿和猴頭菇子實體的熱水萃取物，分別對巨噬細胞株存活率、NO產生及細胞激素包括TNF-α、IL-4及IL-10生 成量的影響。結果顯示，低濃度 (10 μg/mL) 猴頭菌液態發酵米漿熱水萃取物未造成巨噬細胞株傷害，存活率超 過100%。猴頭菌液態發酵米漿及猴頭菇的熱水萃取物濃度為5及50 μg/mL均可促使巨噬細胞增加NO、TNF-α、 IL-4及IL-10的生成量，故猴頭菌發酵米漿及猴頭菇子實體皆具有調節免疫之效果。

Hericium erinaceus can enhance immunity and has remarkable effects on gastric cancer and gastric ulcer. The objectives of this study were to evaluate the hot water extracts of Hericium erinaceus fermented rice milk and fruiting bodies, respectively, on macrophage proliferation, production of NO, and secretion of TNF-α, IL-4 and IL-10. The results showed that low levels of hot water extract from Hericium erinaceus fermented rice milk at 10 μg/mL did not harm macrophages, and the survival rate was over 100%. The hot water extract of Hericium erinaceus fermented rice milk and fruiting bodies at 5 μg/mL and 50 μg/mL could significant induce macrophages to secrete NO, TNF-α, IL-4 and IL-10. Therefore, the water extracts of Hericium erinaceus fermented rice products and fruiting bodies had competence of immune modulation ability.