原發性食道類淋巴上皮癌（LELC）是一種非常罕見的疾病，在醫學文獻只有 29 例報導的案 例。此腫瘤的特徵是未分化細胞混合有緻密的淋巴細胞浸潤，在多數文獻報告中指出和 EBV 的 DNA 相關。在本篇報告中提出一名 52 歲的男性患者被診斷為第四期（cT3N2M1）食道中下段 LELC ，到院時主訴有 3 個星期的時間吞嚥困難。該患者利用同步化療和放射治療（CCRT）治療 成功。治療後 12 個月對食道再進行一次切片顯示腫瘤完全緩解，追蹤 24 個月病患仍然存活且沒 有復發，目前仍繼續門診追蹤。

Primary lymphoepithelioma like carcinoma (LELC) of the esophagus is a very rare disease; only 29 cases were reported in the medical literature. This type of tumor is characterized by undifferentiated cells mixed with dense lymphocytic infiltration. Here we would like to present a 52 year old male patient who was diagnosed with stage IV (cT3N2M1) LELC of the middle to lower esophagus. The patient’s chief complaint was dysphagia of 3 weeks duration. The patient was successfully treated with concurrent chemotherapy (PF4 regimen) and radiotherapy (5040 cGy). A repeat esophageal biopsy done 12 months after concurrent chemoradiation therapy (CCRT) revealed no evidence of tumor. This patient is alive and disease-free 24 months after CCRT.