篇名 | Impact of Statins Therapy for Ischemic Heart Disease Patients with Low-Density Lipoprotein Cholesterol Levels Less Than 100 mg/dL |
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卷期 | 32:5 |
作者 | Masanori Kuwabara 、 Fumiaki Kondo 、 Tomoyuki Hamada 、 Jun-ichi Takahashi 、 Nanae Takenaka 、 Takashi Furuno |
頁次 | 565-569 |
關鍵字 | Ischemic heart disease 、 Low-density lipoprotein cholesterol 、 Secondary prevention 、 Statins 、 MEDLINE 、 SCI 、 Scopus |
出刊日期 | 201609 |
DOI | 10.6515/ACS20151013E |
Background: The objective of this study was to determine whether the use of statins prevents the progression of ischemic heart disease (IHD) in patients with low levels of low-density lipoprotein cholesterol (LDL-C). Methods:We reviewed data obtained from IHD patients who underwent first percutaneous coronary intervention (PCI). Patients underwent follow-up coronary angiography (re-CAG) after PCI. However, only patients with LDL-C levels less than 100 mg/dL at PCI were included in this study. Ultimately, 92 patients were enrolled. All patients were divided into two groups: 1) patients who were treated with statins (n = 69), and 2) patients who were not treated with statins (n = 23). Results: The two groups had similar LDL-C levels at PCI. At re-CAG, the ratio of patients who underwent PCI for de novo lesion in the statin group was lower than that in the non-statin group (12% vs. 48%) (p < 0.001). In multiple regression analysis, statin usage and LDL-C level at PCI were independent predictors of the ratio of patients undergoing PCI for de novo lesion. Conclusions: Statins therapy for patients whose LDL-C levels are less than 100 mg/dL has a beneficial effect on secondary prevention of IHD.