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The Journal of Nursing Research MEDLINESCIEScopusSSCITSSCI

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篇名 Zika Virus Molecular Biology and Perspectives for Vaccine Development: A Review
卷期 25:1
作者 Hsiao-Han LinLi-Min HuangSuh-Chin Wu
頁次 003-006
關鍵字 MEDLINEScopusSSCITSCITSSCISCIE
出刊日期 201703
DOI 10.1097/jnr.0000000000000205

中文摘要

英文摘要

The Zika virus (ZIKV) is a mosquito-borne, positivesense, single-stranded RNA virus that belongs to the genus Flavivirus. ZIKV was first isolated from monkeys in the Zika forest in Uganda in 1947. Since it was first detected in a human in Nigeria in 1952, ZIKV has generally caused cases of human infections in Africa, Asia, and Oceania only rarely. However, in 2007, the first-recorded small-scale outbreak of ZIKV appeared on Yap Island, Micronesia, in which 73%of Yap residents were infected. In 2013, a largescale outbreak occurred in French Polynesia with a population infection rate of 66% (Plourde & Bloch, 2016). Two years later, in March 2015, the first report of a ZIKV outbreak appeared in Bahia, Brazil. Since then, more than 1.5 million cases have been reported in Brazil and the disease has spread throughout South and Central America and the Caribbean. Based on phylogenetic analyses, the ZIKV isolates from this outbreak show a greater than 99% identity to the French Polynesian strain, suggesting that ZIKV was introduced to South America from the French Polynesia epidemic of 2013 (World Health Organization [WHO], 2016a). At present, over 70 countries and territories around the world have reported evidence of mosquito-borne ZIKV transmission, and 12 countries have reported person-to-person transmission, mainly distributed in America, Asia, Africa, and the Pacific regions. Several imported cases of ZIKV infection have also been recorded in Europe, America, Asia, and Australia (WHO, 2016b; Huang, Shu, & Yang, 2016; Wong, Poon, & Wong, 2016).

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