猴頭菇是一種眾所周知的食用和藥用真菌。它的子實體和菌絲體含有豐富的活性成分，包括多醣、萜類 化合物、猴頭素及猴頭酮等，具有免疫調節、抗腫瘤、抗氧化、抗菌、神經保護及增強記憶力等功效。故本 研究之目的為測試猴頭菌固態發酵大豆薏仁產物之水萃取物與乙醇萃取物是否對1%乙醇損傷的斑馬魚胚胎腦 神經細胞具有保護及修復作用。結果顯示，猴頭菌固態發酵大豆薏仁產物之水萃取物中含有65.18%粗多醣， 且其乙醇萃取物中含有10.85%粗三萜，分別為猴頭菇子實體的6.87倍和3.97倍。將斑馬魚胚胎先浸泡不同濃度 (50、100及200 ppm) 猴頭菌固態發酵產物之水及乙醇萃取物24 h，再浸泡於1%乙醇24 h後，則其可減少因1%乙 醇損傷所造成腦細胞死亡數量，且呈現劑量依賴性，以200 ppm效果最佳，已達控制組的水平。此外，猴頭菌 固態發酵產物的200 ppm之水萃取物及乙醇萃取物皆能顯著修復先浸泡1%乙醇4 h所造成斑馬魚胚胎腦細胞之 損傷，且它們的效果顯著比猴頭菇子實體萃取物佳。

Hericium erinaceus is a well-known edible and medicinal mushroom. Its fruiting bodies and mycelia exhibit various bioactive components including polysaccharides, terpenoids, erinacines, and hericenones. It also have various pharmacological activities, such as immunomodulation, antitumor, antioxidant, antimicrobe, neuroprotection and enhancing memory functions. The objective of this study was to investigate protection and repair functions of brain cells in zebrafish embryos by treatment of hot water and ethanol extracts from Hericium erinaceus solid-state fermented soybean and adlay mix products. The results showed that the crude polysaccharide and crude triterpenoids contents in water and ethanol extracts from Hericium erinaceus solid-state fermented soybeans and adlay mix product were 65.18% and 10.85%, respectively. They were 6.87 and 3.97 folds fruiting body extracts. Zebrafish embryos pre-soaking 24 h in different concentrations (50, 100 and 200 ppm) of water and ethanol extracts of Hericium erinaceus solid-state fermented product significantly reduced the number of died brain cells impaired by 1% ethanol soaking 24 h in a dose-dependent, 200 ppm extract had the best protection effect as the control. Moreover, both 200 ppm water and ethanol extracts from Hericium erinaceus solid-state fermented product had significantly better repair effects in brain cells of zebrafish embryo impaired by 1% ethanol pre-soaking 4 h; they also had better effects than extracts from Hericium erinaceus fruiting body.