Goodpasture 症候群是個進展快速且致命的疾病，血清中的抗基底膜抗體被用來診斷這疾 病，但等待這結果相當耗費時間且結果可能呈現偽陰性。腎臟切片是用來確認診斷這疾病的 黃金準則。這個案例正是抗基底膜抗體陰性但腎臟切片以免疫螢光染色下呈現以IgG線狀沉 積在腎絲球基底膜上的分布。病人以疑似肺腎症候群表現來就醫時，必須要考慮做腎臟切片 且儘速開始作脈衝式類固醇給予以及作血漿置換。

Goodpasture syndrome is a rapidly progressive and fatal disease. Serum anti-glomerular basement membrane (GBM) antibody is used for diagnosis, but the test is time-consuming and a false-negative is possible. Most hospitals in Taiwan, the test would be performed when the samples collected up to a certain amount. Thus, renal biopsy is the gold standard for a definite diagnosis. The case presented here was negative for serum anti-GBM antibody, but immunofluorescence microscopy of tissue from a renal biopsy indicated linear deposition of IgG on the glomeruli. Patients who present with suspected pulmonary renal syndrome should be considered for renal biopsy, and pulse corticosteroid therapy with plasmapheresis should be promptly initiated.