This investigation reports the synthesis of copper oxide nanoparticles using different feasible methods and their structural characterization. The synthesis process involved few innovative along with some established procedures by using different precursors to report a comparison study. The synthesized nano particles were characterize from X-Ray Diffraction (XRD) studies, Scanning electron microscopy (SEM) analysis and Energy dispersive X-ray analysis (EDX) for their shapes and sizes. The sizes of the synthesized nanoparticles are in nano scale with spherical structures irrespective of the techniques used. The calculated value of particle size is also confirmed from Debye Scherrer’s formula. EDX spectrum shows the elemental composition of the samples. In addition, XRD peak-broadening analysis was used to evaluate the size and lattice strain from Williamson-Hall plots. Similarly, the band gap energy was evaluated for all the synthesized samples from UV-visible spectrophotometric analysis. Overall, the results of different synthesis methods have come up quite interestingly and appreciably.