目的：評估鼻咽癌病人顱底侵犯對預後的影響和與腦內蔓延之相關性。 材料與方法：本研究包括連續 812 位經組織診斷為鼻咽癌，並以電腦斷層及磁振攝影進行原發 腫瘤蔓延之評估。所有影像均經重新檢視，評估病人影像的腦內蔓延與顱底侵犯狀況。 結果：卵圓孔、顳骨岩部、蝶骨斜坡和翼腭窩之腫瘤侵犯與腦內蔓延相關。顱底侵犯之部位數 目多少有明顯不同之無局部復發存活率。卵圓孔、顳骨岩部和翼腭窩之腫瘤侵犯也同時影響無 局部復發存活率。 結論：包括卵圓孔、顳骨岩部、蝶骨斜坡和翼腭窩的顱底侵犯為鼻咽癌併腦內蔓延之良好預測 因子，除了蝶骨斜坡外之其餘三者也會影響無局部復發存活率。

Purpose : To evaluate the influence of skull base abnormality on prognosis and correlation with intracranial invasion in nasopharyngeal carcinoma (NPC) patients. Materials and Methods : Total 812 consecutive patients with histologically confirmed NPC who underwent staging computerized tomography and magnetic resonance imaging for evaluation of primary tumor extension were enrolled in this study. All radiologic images were reviewed and assessed for intracranial extension and skull base invasion. Results : Tumor invasion of the foramen ovale, petrous portion of the temporal bone, clivus and the pterygopalatine fossa associated with intracranial involvement. The number in site of skull base lesions showed significant differences in local failure-free survival. Foramen ovale, petrous portion of the temporal bone and pterygopalatine fossa involvement also showed impact on local failure-free survival. Conclusions : Involvement of the skull base such as foramen ovale, petrous portion of the temporal bone, clivus, and pterygopalatine fossa could be good predictors of intracranial involvement in NPC and all except clivus affected local failure-free survival.