前言：下咽部之淋巴上皮癌為一種罕見的癌症，此類癌症的細胞型態多發生於鼻咽部。淋巴上 皮癌主要由分化不良型的未角化鱗狀細胞組成，並同時有明顯的淋巴浸潤。在組織病理學和未 分化未角化鼻咽癌非常相近。不同的是下咽部之淋巴上皮癌並不像大多數的鼻咽癌一般，與 EB 病毒有密切的相關性。 病例報告：一名 71 歲的男性，在 2014 年的 8 月被診斷出下咽部之淋巴上皮癌，並在之後緊接 著接受合併化學及放射線治療。在治療結束四個月後，根據影像學上的追蹤可發現腫瘤達到部 分有效；而在九個月後，影像學上的追蹤發現腫瘤達到完全有效。 討論：在這個罕見的晚期下咽部之淋巴上皮癌病人身上，主程性合併化學及放射線治療，在到 目前為止的十五個月中，追蹤發現有不錯的治療效果。不過仍需要更多的案例才能決定出最適 當的治療方式。

Introduction : Lymphoepithelial carcinoma (LEC), mostly seen in the nasopharynx, is a rare cancer of the hypopharynx. LEC is characterized by an undifferentiated non-keratinizing squamous cell carcinoma with a significant lymphocytic infiltration, and is histopathologically similar to non-keratinizing, undifferentiated nasopharyngeal carcinomas (NPC), but is less associated with the Epstein-Barr virus (EBV). Case report : In this study, we report the diagnosis and treatment by concurrent chemoradiotherapy (CCRT) of a 71-year-old male hypopharyngeal LEC patient in Aug 2014. The patient completed the CCRT treatment course. In the follow-up image survey half a year after treatment, a partial tumor response was noted. Further, complete regression was achieved in the following image survey 9 months after treatment. Discussion : In this rare case of advanced stage, non-EBV related hypopharyngeal LEC, a good response to definitive CCRT was achieved within the 15-month follow-up period. However, more patients are required to define the optimal treatment for hypopharyngeal LEC.