Due to lack of comprehensiveness and consideration of customer requirements (CAs) in the design of economics of quality (EOQ) of automobile, we proposed a novel approach integrating quality function deployment (QFD), fuzzy extended analytic network process (FEANP) and multi-segment goal programming (MSGP) techniques to select automobile engineering characteristics (AECs) for designing EOQ in whole life cycle of automobiles (WLCA) to make up these drawbacks. In this paper, QFD is used to translate CAs into engineering characteristics of automobile and the impreciseness and vagueness with human judgments and information during the design process are handled by FEANP. The priorities of AECs with the consideration of the interrelationships between criteria are calculated by the framework of QFD incorporated with FEANP. In addition, a multi-segment goal programming (MSGP) model is formulated by considering the outcome from QFD-FEANP and other automobile goals to select AECs. Finally, a typical application is presented to show the advantage of the approach including the consideration of various automobile goals and the flexibility of setting multi-aspiration levels of evaluation criteria.