臺灣藜 (Chenopodium formosanum Koidz.) 為原住民傳統之糧食作物，又稱為“Djulis”，具有相當高的營養 價值及機能成分以及某些生理功能，如：降膽固醇及提高免疫力等。臺灣藜並非我國農政單位表定之糧食作 物，使政府在推動種植及產品開發上受到相當大的限制，因此急需進行安全性評估證實其食用安全劑量。本 研究將雌、雄大鼠各分為對照組 (AIN-76A飼料)、控制組 (高筋麵粉)、帶殼與不帶殼臺灣藜低、中、高劑量共 八組。將以2倍水加熱糊化之蒸熟帶殼 (WD) 或脫殼 (HD) 臺灣藜混入大鼠飼料 (AIN-76A) 加熱乾燥定型後，製 備成含有7.5、14.1及25.2%之WD及HD飼料。結果顯示，大鼠連續28天食用WD、HD後，所有臺灣藜組別雌雄 大鼠之動物行為、組織/器官重量、組織染色、血液及尿液生化值等，多在正常值範圍內，也與空白組或控制 組無顯著差異 ( p > 0.05)。但餵食高劑量HD組之公、母鼠之血清Glutamic pyruvic transaminase均顯著高於對照組 與控制組 ( p < 0.05)，且高於正常範圍，此種結果顯示餵食高劑量HD具有潛在的肝臟毒性。故本研究以中劑量 (14.1%) 之臺灣藜為攝食安全劑量，換算出成人每日食用臺灣藜之安全劑量範圍約為70.5 g (乾重)，而WD之每 日攝食安全劑量至少可達約126 g (以25.2%之高劑量WD或更高攝取量計算)。

Chenopodium formosanum Koidz is a traditional crop of the aborigines in Taiwan, and is commonly called “Djulis”. Dlulis is rich in nutrients and functional ingredients, and research has shown that it has various biological effects, such as decrease of cholesterol and enhancement of immunity. Because Djulis is not listed as a food crop in many countries including Taiwan, it is difficult to promote its cultivation and product development. Therefore, there is an urgent need to determine the safe intake level of Djulis by safety assessment. In this study, male and female rats were divided into 8 groups: blank (AIN-76A diet), control (high-gluten flour), low-, medium-, and high-dose whole Djulis (WD) or hulled Djulis (HD). To prepare the diets, WD or HD was pre-mixed with 2× water, heated, mixed with rat chow, then dried to form 7.5, 14.1, and 25.2% WD or HD diets. Results revealed that after feeding for 28 days, the behavior, organ/tissue weights, histological stain, and blood and urine biochemistry of rats fed WD or HD were all in the normal range and not statistically different from those of rats fed the blank or control diets. However, plasma glutamic pyruvic transaminase activities in both female and male rats of high-dose HD groups were significantly increased, as compared with those of rats fed the blank or control groups, and were higher than the normal range, suggesting that H-HD may potentially cause liver damage. Based on the medium dose (14.1%), a safe daily intake of HD for human adults is estimated to be 70.5 g (dry weight) while the safe daily intake for WD is at least beyond 126 g (estimated based on 25.2% WD or higher intake).