肺癌在105 年躍居為台灣十大死因中惡性腫瘤的第一位，讓各界越來越重視肺癌的發生 與治療。從過去的根除性手術治療、電療、化學治療和標靶治療都成功延長了許多肺癌病人 的生命也改善了許多病人的症狀。但隨著醫學的進步，科學家和腫瘤專家不斷研究免疫系統 與腫瘤之間一系列的互動機轉，試圖找出腫瘤細胞抑制免疫系統清除的機轉並將以逆轉，重 新激活免疫系統的活性來對抗腫瘤細胞。促使了免疫治療藥物的出現，也將癌症治療帶入了 免疫治療的時代。目前免疫治療在肺癌的治療中取得了不錯的成效。本文將介紹目前台灣核 准使用針對肺癌的免疫治療藥物、機轉、使用條件以及目前臨床實驗的成果。

Lung cancer is the leading cause of cancer-related death in Taiwan now a day. The incidence and treatment strategy of lung cancer became the major issue of society. The management of lung cancer including curative surgery, radiation therapy, chemotherapy and target therapy which improved the patient’s long term survival and the clinical symptoms. Investigation of the relationship between the tumor cells environment with the human immune system and the development of the inhibition mechanism to the immune system by tumor cells promote the arise of Immunotherapy, bringing the treatment of lung cancer into the new era of immunotherapy. We will introduce the development of the immunotherapy of the lung cnacer, current available immunotherapy in Taiwan and their clinical studies result.