“流動床造粒”為粉、粒體製備之重要加工及載體技術之一，其利用黏（著）性做為造粒、成型之核心機 制；如何提高包覆率及粉體品質安定性，是重要研究主題與待突破之技術。本實驗擬以低甲氧基果膠為黏著 劑探討其黏性效應對粉體品質的影響，並使用沃斯特式腔體利用氯化鈣與果膠形成果膠及鈣-蛋殼(egg box) 凝膠作用機制，評估其黏著性及包覆效應。本實驗結果如下：在造粒過程中果膠處理組以4%果膠其粒徑增長 較為快速，包覆120分鐘後以6%果膠粒徑最大181.48um(p< 0.05)，而從流動性實驗中可看出4%果膠造粒粉體 之流動性最佳(CI% = 7.58);而DSC分析中包覆後6%果膠粉體之Tg由88.84t上升至114.32t。藉由DSC與微細構 造之觀察可以發現在包覆實驗中於粉體表面達到產生果膠-鈣之鍵結；模擬釋放之結果中亦可知經過包覆後之 粉體有些微延緩釋放之結果，且對於內部芯材之保護效果亦較為完整。由本研究之結果印證pectin-Ca2+-“egg box”模式系統可達到黏著造粒及包覆保護效果；而從結果中可看出在造粒過程中以4%果膠會有較好的粉體品 質，經過沃斯特式包覆則以6%果膠有較好的包覆品質；盼本研究之結果可對濕式流動床造粒以及沃斯特式包 覆有更深入之了解，未來可供營養、保健、生技產業製品研發及品質改善之參考。

“Fluid bed granulation” is a kind of an important processing and vector technology for manufacturing powders and particles. It use viscosity as its core mechanism for granulation and particle forming. How to enhance encapsulation efficiency and stability is an important studied subject and technology which awaited to be breakthrough. In this study, we use low methoxy pectin as binder to investigate its viscosity effects influenced on the quality of powder. Then, using Wurster chamber to evaluate viscosity and coating effects by the mechanism of “egg - box” gelation which formed by calcium chloride and pectin. The experiment results were as follow: In all pectin treatment , increased particle size most quickly was 4% pectin during granulation process. The biggest particle size after coating 120 minutes was 6% pectin, 181.48 "m (p < 0.05). We could find that the powder granulated by 4% pectin had the best flowability. In thermal analysis (DSC), the glass transition temperature of coated particles was increased from 88.84oC to 114.32oC. With DSC and SEM, we speculated that there was calcium pectinate forming on the surface of particles after coating process. This study proved that calcium pectinate system could provide adhesive granulation and coating to protect the core material. There was the best powder quality granulated by 4% pectin. And the powder coated by 6% pectin had the best coating quality after Wurster coating. We hoped that the result of this study could provide more understanding for fluidized bed granulation and Wurster coating.