Background: As the population ages, the prevalence of various chronic diseases increases. Palliative care for patients at the end of life with a noncancer diagnosis is currently limited because of the difficulties of demarcating the boundaries of the end-of-life care period and of determining the various care needs of patients at the end of life. Purpose: This study aimed to investigate the levels of importance and difficulty of the multidimensional care needs for patients with a noncancer diagnosis during various end-of-life stages. Methods: This study is a retrospective survey. Home healthcare nurse specialists (HHNS) reviewed medical and nursing records and responded to a structured questionnaire. The caring experiences of HHNS with 115 patients, who were 40 years or older, had received home care nursing throughout the stable (between the onset of the end-of-life stage and 1 week before death) and near-death (1 week before death) stages at Seoul St. Mary_s Hospital in Korea, and had died between September 1, 2014, and December 31, 2015, were analyzed. Results: The care needs of Bcoordination among family or relatives[ and Bsupport for fundamental needs[ were more important in the stable stage than in the near-death stage. The care need of Bloss, grief care[ was more important in the neardeath stage than in the stable stage. The care need of Bphysical symptoms management[ was the most difficult to meet in both stages. Lower Palliative Performance Scale score was associated with a higher level of care need, particularly in the Bmanagement of physical symptoms[ and Bpsychological support[ realms in the stable stage and in the Bcoordination among family or relatives[ realm in both stages. Conclusions: End-of-life stage and initial score on the Palliative Performance Scale were found to have a significant influence on the multidimensional care needs of patients with a noncancer diagnosis. Thus, healthcare professionals should assess patient care needs according to disease trajectory to provide continuous and holistic care.