Background: The feeling of safety makes an important contribution to the sense of well-being and quality of care for hospitalized adolescents, who are at a higher risk of feeling unsafe. Feeling unsafe during hospitalizationmay have a negative impact on recovery. Nurses must be sensitive to the possibility that patients feel unsafe, even in the absence of obvious direct physical threat. Purpose: This study explores the experiences of hospitalized adolescents to obtain an understanding of psychological safety. Methods: A qualitative study using unstructured interviews was conducted to explore the sense of psychological safety of hospitalized adolescents aged 12Y18 years and registered in a general medical or surgical pediatric unit. Purposive sampling was used to recruit new qualified participants until data saturation was reached (N = 16). Results: Psychological safety is reflected by the four themes of receiving comprehensive support, protection of human dignity, relaxing environment, and attempts to adapt. Conclusions: Hospitalized adolescents stated that healthcare services should provide comprehensive support in a relaxing environment that allows themto retain their human dignity and that elicits feelings of psychological safety.