緒論：近年來的研究發現急性劇烈或高強度運動會短暫增加血管性血栓發生的風 險。紅景天與冬蟲夏草中草藥已廣泛應用於保健食品市場，做為改善個人生活品質和促 進身體健康之用途。然而，對於結合紅景天和冬蟲夏草對急性劇烈運動後健康之成年人 系統性發炎和凝血功能是否具有正面效益，目前研究仍然不多。方法：本研究採用隨機 雙盲和交叉實驗設計，共十二名健康的成年人 (年齡：21.4 ± 0.4 歲；身高：170.3 ± 6.1 公分；體重：67.3 ± 13.6 公斤) 參與研究，所有參與者分別接受7 天的紅景天與冬蟲夏草 複方 (RC, 20 mg/kg) 或安慰劑補充。所有參與者會進行一小時的運動挑戰 (強度為75% VO2max)。所有實驗參與者之血液檢體分別在運動前及一個小時運動後收集。運動前及運 動後兩小時測量參與者之心律變異度。血液檢體將作為分析系統性發炎反應指標 (嗜中性 球與淋巴球比值，NLR) 及血液凝血指標 (纖維蛋白原、凝血酶原時間、活化促凝血酶原 激酶時間) 之用。安慰劑介入及紅景天與冬蟲夏草複方介入間隔時間為七天。結果：在一 小時劇烈運動挑戰後，RC 介入之纖維蛋白原，嗜中性球/淋巴球比值 (NLR) 和交感神經 活性的變化量顯著低於安慰劑介入。結論：我們的研究發現，RC 補充在劇烈運動後可產 生減緩血液凝固的保護作用，而造成這些保護的效果可能是透過降低運動挑戰後系統性 發炎反應和交感神經活性所達成。

Introduction: Regular exercise or increasing physical activity have been proven that lower the risk of cardiovascular diseases. However, recently evidences indicated acute vigorous or high-intensity exercises have been shown transiently increased the risk of vascular thrombotic events. Both Rhodiola crenulata (R) and Cordyceps sinensis (C) supplements has been widely applied to health food market for improving individual quality of life and promoting human health. Limited studies address the beneficial effects of combining Rhodiola crenulata and Cordyceps sinensis (RC) on reducing systemic inflammation and coagulation in sedentary adults after acute vigorous cycling exercise. Methods: A randomized double-blind and crossover experimental design was conducted in this study. Twelve healthy sedentary individuals (age: 21.4 ± 0.4 years, height: 170.3 ± 6.1 cm, weight: 67.3 ± 13.6 kg) were received either RC (20 mg/kg) or placebo for 7 days. All participants were performed an hour cycling exercise challenge with 75% V ‧O2max intensity. Blood sample collection was conducted at pre-exercise and immediately of one-hour exercise challenge. The HRV measurement was performed at pre-exercise and two hours after exercise challenge. Blood samples were used to analysis the systemic inflammation response (neutrophil/lymphocyte, NLR), and coagulation markers (i.e., fibrinogen, PT, APTT). There was spaced 7 days apart between trials. Results: The change of fibrinogen, NLR and sympathetic nerve activity in RC trial were significantly lowered than in placebo trial after an hour vigorous exercise challenge. Moreover, the change of total power was observed significantly higher in RC trial than in placebo following exercise. No significant difference in parasympathetic nerve activity between trials. Conclusion: Our study demonstrates that provision of an RC supplement provides greater protective effects in attenuating blood coagulation after a vigorous exercise. These benefits from RC treatment might be due to reduce systemic inflammatory response and sympathetic nerve activity following exercise challenge.