篇名 | Pulmonary Artery Distensibility is Worsened in Obstructive Sleep Apnea Syndrome |
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卷期 | 35:5 |
作者 | Emir Karacaglar 、 Ugur Bal 、 Serpil Eroglu 、 Ayse Colak 、 Serife Bozbas 、 Haldun Muderrisoglu |
頁次 | 501-507 |
關鍵字 | Echocardiography 、 Pulmonary artery hypertension 、 Right ventricular function 、 MEDLINE 、 Scopus 、 SCIE |
出刊日期 | 201909 |
DOI | 10.6515/ACS.201909_35(5).20190424A |
Background: Obstructive sleep apnea syndrome (OSAS) leads to right ventricular (RV) dysfunction and pulmonary hypertension (PH) in the later stages. Early determination of these conditions is very important. Objectives: We aimed to evaluate the correlations of pulmonary artery distensibility, right pulmonary artery fractional shortening (RPA-FS), and pulmonary artery stiffness (PAS) with PH among newly diagnosed OSAS patients. Methods: We prospectively evaluated 34 newly diagnosed OSAS patients and 28 controls. The study subgroups were determined according to the apnea-hypopnea index (AHI). All patients underwent a transthoracic echocardiographic examination. Conventional RV parameters, PAS, and RPA-FS parameters were measured. Results: RPA-FS was significantly lower in the OSAS group (p < 0.001) and positively correlated with tricuspid annular systolic excursion (TAPSE) (p = 0.047) and pulmonary acceleration time (PAT) (p = 0.006), and inversely correlated with systolic pulmonary artery pressure (sPAP) (p = 0.013), and PAS (p < 0.001). Consistent with this result, PAS was significantly worse in the patients with OSAS compared to the controls (27.1 ±3.5 to 15.8 ±2.7, p < 0.001), and inversely correlated with RPA-FS (p < 0.001), PAT (p = 0.001), and TAPSE (p = 0.035). PAS was positively correlated with sPAP (p = 0.001). There were statistically significant differences for both PAS and RPA-FS among the OSAS subgroups with regards to the severity of disease (p < 0.001). The correlation analyses showed a significantly positive correlation between RPA-FS and mean O2 saturation. RPA-FS was also inversely correlated with AHI. Similarly, PAS was positively correlated with AHI and arousal index. Conclusions: PAS and RPA-FS areworsened in patients with OSAS, and are correlated with PH and severity of OSAS.