目的：慢性腎臟病在全世界的盛行率逐年攀升，台灣的洗腎人口也一直居高不下。近年來有些許研究顯示三酸甘油酯與高密度脂蛋白膽固醇的比值(triglycerides to high-density lipoprotein cholesterol ratio, TG/HDL-C)和腎功能有相關性，但都未涉及醫療從業人員。本研究藉由分析醫療從業人員的體檢資料，來探討TG/HDL-C和腎功能的關聯性。方法：本研究為橫斷面的研究，收錄台灣北部某醫院員工年度健檢報告。腎功能以腎絲球過濾估計值(estimated glomerular filtration rate, eGFR)來估算，並把TG/HDL-C分成三組。統計方面則以變異數分析(ANOVA)和卡方檢定(chi-square test)來分析三組間的差異性。進一步用皮爾森相關係數分析TG/HDL-C與eGFR的關係。最後利用單變項與多變項線性迴歸分析求得TG/HDL-C對eGFR的預測能力。結果：本研究收錄2014年到2018年在北部某醫院體檢的員工共1312人納入分析。結果發現三組間的TG/HDL-C與eGFR有統計上顯著的差異(p<0.001)。而在校正了年齡之後，計算TG/HDL-C與eGFR的皮爾森相關係數，得知兩者亦呈現負相關性。最後多變項線性迴歸分析發現TG/HDL-C與eGFR呈負相關(B=-1.90, 95% CI -2.71~-1.08)。結論：TG/HDL-C與 eGFR呈負相關。對於TG/HDL-C高的勞工，醫師可提早介入和衛教，預防之後慢性腎臟病的發生。

Background and Purpose: The incidence of chronic renal failure has been increasing globally over the years. Locally in Taiwan, the population of people undergoing dialysis remains high. Recent publications have shown an association between triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) and renal function. However, none of the studies involved health-care employees. Therefore, the aim of this study is to explore the relationship between TG/HDL-C and renal function among health-care employees in Taiwan. Methods: This is a cross-sectional study which analyzed the annual health checkup data of health-care employees in a hospital in Northern Taiwan. Renal function is represented as eGFR. Three groups are formed according to TG/HDL-C. ANOVA and the chi-square test were used to compare the demographic and clinical characteristics between the three groups. Further analysis was done using the Pearson's correlation coefficient. Finally, univariate and multivariate linear regression analyses were used to find the ability of TG/HDL-C to predict eGFR. Results: This study enrolled a total of 1312 health-care employees from a hospital in Northern Taiwan from 2014 to 2018. The differences in eGFR between the three groups of TG/HDL-C were statistically significant (p<0.001). After adjustment for age differences and calculating the Pearson's correlation coefficient, a negative correlation was found between TG/HDL-C and eGFR. Final multivariate linear regression analysis revealed that TG/HDL-C and eGFR have a negative correlation (B=-1.90, 95% CI -2.71~-1.08). Conclusion: TG/HDL-C and eGFR have a negative correlation. Early intervention of employees with high TG/HDL-C can be conducted to prevent future development of chronic kidney disease.