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中華職業醫學雜誌

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篇名 EBV病毒感染導致嗜血性組織球暨淋巴球增多症之胸腺氟化去氧葡萄糖攝取增加:一病例報告
卷期 26:4
並列篇名 Glucose Hypermetabolism in Thymus in a Patient with Hemophagocytic Lymphohistiocytosis Secondary to EBV Infection: a Case Report
作者 楊宗翰周育祥程紹智
頁次 295-300
關鍵字 EB病毒氟-18-氟化去氧葡萄糖正子電腦斷層掃描嗜血性組織球暨淋巴球增多症胸腺Epstein-Barr virusF-18-FDG PET/CT scanHemophagocytic lymphohistiocytosisthymusTSCI
出刊日期 201910

中文摘要

氟-18-氟化去氧葡萄糖正子電腦斷層掃描因能敏感地辨認出由淋巴癌觸發之嗜血性組織球暨淋巴球增多症,因而被倡應用於嗜血性組織球暨淋巴球增多症的臨床處置中。我們報告一位患有嗜血性組織球暨淋巴球增多症的十九歲女性病人,她的氟-18-氟化去氧葡萄糖正子電腦斷層掃描影像呈現氟化去氧葡萄糖攝取增加於胸腺,即在動物模型中當胸腺發生EB病毒感染時可造成類似的免疫紊亂之部位。氟-18-氟化去氧葡萄糖正子電腦斷層掃描可能有潛力釐清嗜血性組織球暨淋巴球增多症的各種肇因,並對疾病處置帶來幫助。

英文摘要

Fluorine-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography with computed tomography (PET/CT) scan has been advocated in the management of hemophagocytic lymphohistiocytosis (HLH) because it sensitively recognizes patients with lymphoma-associated HLH. We report a 19-year-old female patient with HLH secondary to Epstein-Barr virus (EBV) infection whose F-18-FDG PET/CT scan demonstrated increased FDG uptake in the thymus, a site in which EBV infection may result in immune derangement in animal models. F-18-FDG PET/CT may have the potential to clarify various triggers of HLH and to assist in its management.

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