局部投予（topical delivery)藥物是標靶治療皮膚疾病的有效方式。藥物發揮藥理活性，其活性成分須先經由皮膚吸收，才能達到治療效果。許多因素都會影響藥物經皮傳輸，包括：結構、物化性質、載體種類及與皮膚間交互作用等。藉由藥物之物化性質與結構預測其經皮吸收能力，對於選擇和設計藥物運用於局部投予治療是目前主要研究方向之一。本論文回顧了利用黃酮類化合物(flavonoids)為硏究模型，探討其結構差異對於其經皮吸收能力影響。結果顯示羥基之數量、位置對於flavonoids經皮傳輸皆有影響，naringenin具有較高的經皮吸收能力，可做為新一代皮膚美容產品的候選活性成分。我們嘗試建立化合物之結構-穿透相關性（structure-permeation relationship)，期望能運用於局部皮膚投予的設計與評估，以期讓使用者能獲得更安全有效的治療。

Topical delivery can be an efficient method for skin targeting and cutaneous disease management. The actives must first be absorbed by the skin if the drugs are to provide therapeutic benefits. Various factors can influence this process, including the structure and physicochemical characteristics of the drugs, the vehicles into which the drugs are loaded and the interaction between the drugs and skin. An elucidation of how the physicochemical factors and structure affect drug absorption is important for selecting and designing feasible drugs for topical application and is the main research direction of local skin delivery at present. This review article employed the flavonoids as the research model. Flavonoids cutaneous absorption capactiy is affected by the number and location of hydroxyl groups. Naringenin maintained a better cutaneous absorption capacity, so it can be a candidate for the new generation of skin beauty products. We attempted to established structure-permeation relationship. We hope it will be used for the design and evaluation of local skin delivery, so users can get safer and more effective treatments.