篇名 | Comparison of 9-Month Angiographic Follow-Up and Long-Term Clinical Outcomes of Biodegradable Polymer Drug-Eluting Stents and Second-Generation Durable Polymer Drug-Eluting Stents in Patients Undergoing Single Coronary Artery Stenting |
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卷期 | 36:2 |
作者 | Ming-Lung Tsai 、 Ming-Jer Hsieh 、 Chun-Chi Chen 、 Shang-Hung Chang 、 Chao-Yung Wang 、 Dong-Yi Chen 、 Chia-Hung Yang 、 Jih-Kai Yeh 、 Ming-Yun Ho 、 I-Chang Hsieh |
頁次 | 097-104 |
關鍵字 | Coronary artery disease 、 Drug-eluting stent 、 Major adverse cardiac events 、 Polymer 、 MEDLINE 、 Scopus 、 SCIE |
出刊日期 | 202003 |
DOI | 10.6515/ACS.202003_36(2).20190729A |
Background: The durable polymers (DP) used in first-generation drug-eluting stents (DESs) were associated with long-term cardiovascular events, and thus biodegradable polymer DESs (BP-DESs) and second-generation DP-DESs were designed to overcome this problem. In this study,we compared angiographic follow-up and long-term clinical outcomes between patients who received BP-DESs or second-generation DP-DESs. Method: We enrolled 436 patients with single coronary lesions who received a second-generation DP-DES or BP-DES between June 2009 and October 2012. All patients received follow-up angiography when new clinical events developed or at 9 months after index stenting. All participants received follow-up for 5 years. Result: There were no significant differences in patient and lesion characteristics between the two groups. The 9-month angiographic follow-up showed a lower net gain in the second-generation DP-DES group (2.19 mm vs. 2.41 mm, p = 0.040), but a similar binary restenosis rate between the two groups (5.4% vs. 8.7%, p = 0.276). During the 5-year follow-up period, no significant differences were observed between the two groups in major adverse cardiac events (MACEs), cardiovascular death, nonfatal myocardial infarction (MI), target vessel revascularization (TVR), all revascularization, stent thrombosis (ST), orMACE-free survival. Conclusions: No significant differences were observed in cardiovascular death, nonfatal MI, TVR, all revascularization, ST, or MACE-free survival between the patients undergoing single coronary artery stenting with BP-DESs and second-generation DP-DESs.