結晶型游離二氧化矽之化學特性穩定，廣泛為各種產業使用，該化合物進入肺部便不易排出，引發相關健康效應。國際癌症研究中心（The International Agency for Researchon Cancer; IARC）根據已知流行病學證據認定其致癌物質分類為Group l，即確定人類致癌物質。一位58歲男性，從事噴砂工作30餘年，後被診斷出肺癌，其所從事之噴砂工作，經常暴露於含有二氧化矽粉塵中。綜合其工作史，影像學檢查，肺部病理報告及流行病學研究，排除其他可能致病因素後，認為其二氧化矽暴露引起之肺癌。

Free crystalline silica is very inert and widely used in industries. While entering human body, free crystalline silica will stay in lung for a long time, and cause healthy effects such as silicosis and lung cancer. The International Agency for Research on Cancer had grouped free crystalline silica as Group I, Carcinogen to humans, since 1997. In this article, we will discuss a sandblasting worker who was diagnosed lung squamous cell carcinoma after working over 30 years. Then we reviewed studies to explore association between his workplace exposure and disease.