肢體麻木及無力為神經科臨床常見症狀，鑑別診斷從中樞到週邊神經系統疾病都有可能。一位69 歲男性主訴雙手感覺麻木後、漸進發生雙下肢肢體麻木、無力及行走困難；七週後出現右側顏面麻痺及口齒不清等神經學症狀。住院探查病因後，確診為慢性脫髓鞘多發性神經炎(Chronic inflammatory demyelinating polyneuropathy, CIDP)。選擇免疫球蛋白治療(Immunoglobulin therapy)，效果良好，恢復自行走路、提重物及駕駛。出院後仍因肌無力週期性復發入院，對免疫球蛋白治療皆反應良好。慢性脫髓鞘多發性神經炎(CIDP) 於臨床少見，症狀表現多樣化，而且缺乏特定診斷標記，常導致困難診斷甚至誤診。盼藉此病例報告分享，能早期辨識此疾病，轉介專科合作，積極治療，減少不可逆之神經學缺失。本文將就CIDP 病史、鑑別診斷、病理病因學及治療深入討論。

Limb numbness and weakness are common symptoms in Neurology Clinics, and diseases ranging from central to peripheral nervous system are all the possible differential diagnosis. A 69-year-old male patient presented with numbness in bilateral hands and then progressive numbness in lower limbs. He was initially treated as cervical spondylosis, but his condition did not improve after several weeks of medication and physical therapy. As neurological symptoms of progressive difficulty in walking, facial palsy, and dysarthria developed a few weeks later, he was admitted at our hospital. Under detailed medical record investigation and examination, the diagnosis of Chronic inflammatory Demyelinating Polyneuropathy (CIDP) was established. With periodic treatment course of intravenous immunoglobulin therapy, the patient could walk, run, and drive. CIDP is an uncommon disease; its nonspecific symptoms and lack of specific diagnostic markers often lead to a difficult diagnosis or even misdiagnosis. By sharing this case report, we believe CIDP can be identified earlier and referred to specialists for appropriate treatments which significantly reduce the irreversible neurological deficit.