過去研究顯示焦慮是女性乳癌病人，化學治療期間影響其生活品質的主要原因之一。研究發現彩繪曼陀羅能作為緩解焦慮情緒的輔助療法。因此，本研究採實驗性隨機分配研究設計法，針對台灣南部某區域教學醫院接受化療的女性乳癌病患，探討介入彩繪藝術活動對緩解其焦慮和影響生理反應之成效。於2018年2月至2019年4月期間，隨機分為彩繪曼陀羅組12名、格子畫組11名、自由畫組12名及對照組12名完成前後測實驗。結果發現彩繪曼陀羅能顯著降低病人焦慮量表得分由44.9降至33.7分(p=0.034)，但格子畫及自由畫則不能有效改善，各組試驗前後之血壓與心跳並未因彩繪活動而受影響。本研究顯示彩繪曼陀羅能有效降低乳癌病患在接受化學治療期間的焦慮困擾。證實彩繪曼陀羅能做為乳癌病患降低焦慮之照護措施。未來將可進行研究評估彩繪曼陀羅應用於緩解接受臨床治療的癌症病患，降低焦慮情緒之效應。

Previous studies showed that anxiety disorders were one of the most prevalent problems affecting the quality of life in breast cancer patients undergoing chemotherapy. Coloring in mandala drawings has been suggested as an adjuvant therapy for breast cancer to relief anxiety. Therefore, the present study aimed to investigate the potential effects of coloring art activities on anxiety reduction and physiological responses in hospitalized female breast cancer patients receiving chemotherapy at one regional teaching hospital in southern Taiwan. All participants were recruited and assigned to the coloring mandala (n=12), plaid drawing (n=11), free-from drawing (n=12), and control groups in a randomized control trial (RCT) from February 2018 to April 2019. Analyzed results showed that the State-Trait Anxiety Inventory scores in the coloring mandala group were notably reduced from 44.9 to 33.7 (p=0.034). There were no significant changes after the intervention of coloring activities with respect to physiological responses. Overall, the present study revealed that coloring in mandala drawings could effectively reduce the levels of anxiety in breast cancer patients receiving chemotherapy. Coloring in mandala drawings can be used as a means to reduce anxiety in breast cancer patients. Future studies can be carried out to evaluate the effectiveness of coloring in mandala drawings in cancer patients receiving clinical care.