偏頭痛是最常見的神經系統疾病之一，常見症狀有頭痛及伴隨噁心、嘔吐、畏光，甚至對味覺、聲音敏感症狀出現。目前偏頭痛治療使用藥物目的在降低偏頭痛發作頻率、嚴重程度和持續的時間。治療偏頭痛通常合併預防性治療與早期介入急性發作，偏頭痛的早期治療方法包括多種不同類別的藥物，例如：非類固醇抗發炎藥物(nonsteroidal anti-inflammatory drugs, NSAIDs)、鴉片與非鴉片鎮痛藥、巴比妥類藥物、止吐藥、麥角生物鹼及血清素受體作用劑等，近年來，有許多新機轉的藥物上市，例如：5-hydroxytryptamine 1F (5-HT1F)受體作用劑以及降鈣素相關基因肽拮抗劑(calcitonin gene-related peptide antagonists, CGRP)，本文將介紹這些新機轉治療及預防偏頭痛的藥物。

Migraine is one of the most common neurological diseases. The common symptoms are headache, accompanied by nausea, vomiting, photophobia, taste and sound sensitivity. The current medication for migraine treatment is to reduce the frequency, severity and duration of migraine attacks. The treatment of migraine is often combined with prophylactic treatment and early interventional acute attacks. Early treatments for migraine include many different classes of drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs), opium and non-opiate analgesics, barbiturates, antiemetics, ergot alkaloids, and serotonin receptor agents, etc. In recent years, many new drugs have been launched, such as 5-hydroxytryptamine 1F (5-HT1F) receptor agents and calcitonin gene-related peptide antagonists (CGRP). This article will introduce these new drugs to treat and prevent migraine.