In modern society, the migraine is a common disease. In order to improve accuracy of diagnosis, patients need to keep diaries logging headaches during periods of migraine treatment. Physicians can thereby make diagnoses and keep track of headache and migraine episodes through diary entries. Some hospitals may provide patients with paper diaries for recording purposes, though they are not easy to carry, nor are they convenient to save for patients with long-term problems. As a result, this study constructs a special mobile medical application (APP) prototype for migraines and cooperates with the Neurology Department of Taipei Veterans General Hospital, a Medical Center in Taiwan. The app can transform patients’ headache diaries into electronic data and upload it to a database for future access and retrieval. Diary records are displayed not only on mobile platforms (e.g. smartphones, tablet computers), but also on user interfaces via the web. This can be used to help other research concerning migraines, which needs large amounts of collected headache data. Moreover, physicians can improve the efficiency of treatment and accuracy of diagnosis; they can use data that has been automatically processed by the diary app. The purpose of this study is to reduce the reading time of diaries, improve efficiency of diagnosis, solve problems with paper diaries (such as being difficult to keep, read, and transport, uploading headache diaries to databases, and providing data for analysis).